Aubrey de Gray

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Aubrey de Gray

Aubrey David Nicholas Jasper de Gray (born April 20, 1963 in London ) is a British bioinformatician and theoretical biogerontologist living in Cambridge . He is the scientific director of the SENS Foundation, which he co-founded, and the founder of the Methuselah Mouse Prize .

In addition, de Gray is an Associate Professor of the Moscow Institute of Physics and Technology and a member of the Gerontological Society of America , the American Aging Association, and the Institute for Ethics and Emerging Technologies .

Live and act

According to him, Aubrey de Gray never met his father, while his mother, an artist, encouraged him to study science and math - areas where she was rather weak. He was tutored at House School and Harrow School in Sussex during his childhood and youth . Even as a child he wanted to "create something special" according to his own statements.

De Gray later attended the University of Cambridge and studied at Trinity Hall . In 1985 he graduated with a bachelor's degree in computer science . Working as a computer technician at the Department of Genetics at Cambridge University in England , de Gray focused on developing artificial intelligence for automation , believing that hard physical work was inhumane.

He turned to biology in the late 1990s because his wife, Adelaide de Gray (nee Carpenter), is a geneticist and an expert in electron microscopy.

De Gray found that aging and, above all, its control were not as much in the focus of biologists and medical professionals as he had believed. Therefore, he decided to self-taught to acquire the appropriate knowledge to solve the problem himself. In 1999 he published his book "The Mitochondrial Free Radical Theory of Aging" (in German: "The mitochondrial theory of the free radicals of aging"), in which he suggested that the removal of damage to mitochondrial DNA is healthy Could significantly increase service life. However, he already admitted that cumulative damage to the mitochondria is a major cause of senescence , but by no means the only dominant cause. Based on this book, the University of Cambridge de Gray awarded a doctorate (Ph.D.) in biology in 2000.

In 2003, Aubrey de Gray founded the Methuselah Mouse Prize , a competitive award for researchers trying to artificially extend the lifespan of house mice. He wants to increase competition in the field of biogerontology and, if necessary, to uncover and eliminate errors in his own theories through different approaches. In 2007, de Gray co-wrote the book Ending Aging with Michael Rae . In addition to the theory of free radicals, it contains six other suspected cellular and molecular causes of aging / old-age diseases. For each of the known damage classes, which he calls the “seven deadly sins of aging”, he proposes the use of regenerative medicine on a molecular and cellular level as a means of combating them.

In 2018, he presented a solution to the Hadwiger-Nelson problem .

Strategies for Engineered Negligible Senescence - SENS

Aubrey de Gray develops theories about human aging , which, like a disease, he traces back to unfavorable biochemical processes that can be stopped or reversed through targeted manipulation. The method proposed by de Gray, which he describes as Strategies for Engineered Negligible Senescence, SENS for short , is based on seven points of attack he advocated. In 2009 he co-founded the SENS Foundation with Michael Kope, Jeff Hall, Sarah Marr and Kevin Perrott , a non-profit organization to fight aging.

Socially established perspectives and a lack of public discussion on this topic would hinder the application and targeted research in this area. In order to achieve the goal, both the social and political approval and the appropriate equipment with research funds, such as AIDS research, are necessary. (The global US program to combat AIDS, PEPFAR ( President's Emergency Plan for AIDS Relief ), initiated in 2003, earmarked 15 billion US dollars for the fight against AIDS in developing countries from 2003 to 2008 alone.)

Scientific acceptance

Aubrey de Grey's scientific article appeared in various specialist journals and also outside of scientific circles he attracted attention with his thesis that unlimited human life could potentially be achieved in 25 years. De Gray argues that the basic knowledge needed to develop therapies to combat aging already largely exists today. However, his views are controversial.

The Rostock demographer James Vaupel thinks it is entirely possible that "some things that de Gray says could be true". The British researcher is, however, "too optimistic about the speed of this development".

In 2005, MIT's Technology Review, in collaboration with the Methuselah Foundation, awarded a US $ 20,000 prize to the molecular biologist (s) who were able to prove that SENS was "so wrong that it is unworthy of scientific debate" . This came in response to violent and personal criticism of Aubrey de Gray by colleagues: Richard Miller, biogerontologist at the University of Michigan, declared de Gray, for example, to be "dangerous" because he "brings gerontology into disrepute with his promises of salvation", while Sherwin Nuland, professor of clinical surgery in the School of Medicine at Yale University, was fortunate to have “that his [de Grays] lofty plans are most likely to fail, since otherwise his attempt to keep us is certain to our annihilation would lead ".

The arbitrators on this matter were Rodney Brooks, Anita Goel, Vikram Sheel Kumar, Nathan Myhrvold and Craig Venter . Five papers were submitted, three of which met the conditions of the challenge. De Gray wrote a contradiction for each essay, as required by the rules, and the challengers wrote responses. The arbitrators then concluded that none of the challengers had been able to refute SENS, but the magazine felt that one of the refutations was particularly eloquent and well-written, and the submitter received $ 10,000.

At a panel discussion on April 25, 2012, Aubrey de Gray was sharply criticized by Colin Blakemore.

Awards

In 2004 de Gray was awarded the “HG Wells Award for Outstanding Transhumanist Contributions of the Year” by the World Transhumanist Association. For 2020 he was awarded the David P. Robbins Prize of the Mathematical Association of America (MAA).

Fonts

  • Aubrey De Gray, Michael Rae: Never Old! This is how aging can be reversed. Advances in Rejuvenation Research . Transcript, Bielefeld 2010, ISBN 978-3-8376-1336-0 .
  • Aubrey De Gray: The Mitochondrial Free Radical Theory of Aging . Landes Bioscience, 1999, ISBN 1-57059-564-X .

Othello / Reversi

De Gray is also a successful Othello player. He took part in several British and European championships in the 1990s and early 2000s. Its highest rating was dated from the end of 1992 and was 2037 points.

Aubrey opening

The opening F5d6C3d3C4b3 is also called Aubrey because de Gray usually plays it.

Web links

Individual evidence

  1. ↑ This Man Would Have You Live A Really, Really, Really, Really Long Time. If a mouse can survive the equivalent of 180 years, why not us? Or our kids? Scientific provocateur Aubrey de Gray has a plan. Retrieved October 26, 2014.
  2. ↑ Those who want to die can continue to do so. Retrieved October 26, 2014.
  3. ↑ This Man Would Have You Live A Really, Really, Really, Really Long Time. If a mouse can survive the equivalent of 180 years, why not us? Or our kids? Scientific provocateur Aubrey de Gray has a plan. Retrieved October 26, 2014.
  4. ^ The 25-Year Wait for Immortality. Interview with "livescience.com" in which de Gray describes his career as a computer scientist, accessed on October 26, 2014.
  5. ↑ Do you want to live forever. Technology Review Article, Retrieved October 27, 2014.
  6. ^ The 25-Year Wait for Immortality. Interview with "livescience.com", in which de Gray describes his career as a computer scientist, accessed on October 26, 2014.
  7. ^ Andrzej Bartke, Holly Brown-Borg: Life extension in the dwarf mouse . In: Current topics in developmental biology . tape 63 . Geriatrics Research, Department of Medicine, Southern Illinois University School of Medicine, 2004, p. 189-225 , PMID 15536017 .
  8. ↑ Aubrey de Gray, Michael Rae: Never Old! This is how aging can be reversed. Advances in Rejuvenation Research . Transcript Verlag , Bielefeld 2010, ISBN 978-3-8376-1336-0 .
  9. ^ A. de Gray, The chromatic number of the plane is at least 5, arXiv: 1804.02385
  10. ^ Archive of the summaries on the SRF website. Retrieved October 26, 2014.
  11. ↑ web.worldbank.org
  12. ↑ Aging is definitely unhealthy. In: Süddeutsche Zeitung. Interview (German) Retrieved October 26, 2014.
  13. ↑ Rafaela von Bredow: The Abolition of Dying . In: Der Spiegel . No. 30 , 2005 ( online ).
  14. ↑ Jason Pontin: Is Defeating Aging Only a Dream? In: Technology Review. July 11, 2006, accessed October 26, 2014 .
  15. ^ Daniel Kimbel: "This house wants to defeat aging entirely"; Dr de Gray to debate Professor Colin Blakemore in Oxford, April 25th. SENS Research Foundation, April 17, 2012, accessed October 26, 2014 .
  16. ↑ youtube.com
  17. ^ Aubrey de Gray wins 2004 HG Wells Award. ( Memento of the original from May 11, 2016 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. WTA website. Retrieved October 26, 2014.  @1@ 2Template: Webachiv / IABot / www.transhumanism.org
  18. ↑ Aubrey de Gray at the World Othello Federation
personal data
SURNAME De Gray, Aubrey
ALTERNATIVE NAMES De Gray, Aubrey David Nicholas Jasper (full name)
BRIEF DESCRIPTION British biogerontologist and bioinformatician
DATE OF BIRTH April 20, 1963
PLACE OF BIRTH London