CCL5

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CCL5
CCL5
according to PDB  1EQT
other names
  • RANTES
  • Chemokine (CC Motif) ligand 5
  • SIS delta
  • D17S136E
  • TCP228
  • Eosinophil Chemotactic Cytokines
  • T-Cell Specific Protein P288
  • Beta chemokines
  • EoCP
  • Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted
  • Small Inducible Cytokine Subfamily A (Cys-Cys), member 5;
  • CC Motif Chemokine 5

Existing structural data : 1B3A , 1EQT , 1HRJ , 1RTN , 1RTO , 1U4L

Properties of human protein
Mass / length primary structure 91 amino acids, 9990 Da
Identifier
External IDs
Orthologue
human House mouse
Entrez 6352 20304
UniProt P13501 P30882
PubMed search 6352 20304

CCL5 ( English CC-chemokine ligand 5 ) is a cytokine belonging to the family of the C-C chemokines .

properties

CCL5 is involved in inflammatory processes. CCL5 is produced by cytotoxic T cells and binds T cells , monocytes and eosinophils by binding the receptors CCR3 , CCR5 and CCR1 . CCL5 activates the GPCR GPR75 .

CCL5 is involved in the defense against infections with HIV- 1 because it competitively inhibits the binding of HIV to its coreceptor CCR5 .

Individual evidence

  1. ↑ Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS: Cloning, expression, and characterization of the human eosinophil eotaxin receptor . In: J. Med.. . 183, No. 5, May 1996, pp. 2349-54. doi : 10.1084 / jem.183.5.2349 . PMID 8642344 . PMC 2192548 (free full text).
  2. ↑ a b c Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J: Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils . In: Eur. J. Immunol. . 31, No. 7, July 2001, pp. 2170-8. doi : 10.1002 / 1521-4141 (200107) 31: 7 <2170 :: AID-IMMU2170> 3.0.CO; 2-D . PMID 11449371 .
  3. ↑ Slimani H, Charnaux N, Mbemba E, Saffar L, Vassy R, Vita C, Gattegno L: Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages . In: Biochim. Biophys. Acta . 1617, No. 1-2, October 2003, pp. 80-8. doi : 10.1016 / j.bbamem.2003.09.006 . PMID 14637022 .
  4. ↑ a b Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, Trkola A , Marchant D, Clapham PR, Wells TN: The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity . In: J. Biol. Chem. . 276, No. 14, April 2001, pp. 10620-6. doi : 10.1074 / jbc.M010867200 . PMID 11116158 .
  5. ↑ Ignatov A, Robert J, Gregory-Evans C, Schaller HC: RANTES stimulates Ca2 + mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75 . In: Br. J. Pharmacol. . 149, No. 5, November 2006, pp. 490-7. doi : 10.1038 / sj.bjp.0706909 . PMID 17001303 . PMC 2014681 (free full text).
  6. ↑ Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P: Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8 + T cells . In: Science . 270, No. 5243, December 1995, pp. 1811-5. doi : 10.1126 / science.270.5243.1811 . PMID 8525373 .