Complement Decay Accelerating Factor

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Complement decay accelerating factor
Complement decay accelerating factor
according to PDB  1H03
other names

CD55, DAF, CROM, TC, Cromer blood group

Existing structural data : PDB  1H04 , PDB  1H2P

Properties of human protein
Mass / length primary structure 381 amino acids , 41,400 Da
Identifier
External IDs
Orthologue (human)
Entrez 1604
Ensemble ENSG00000196352
UniProt P08174
Refseq (mRNA) NM_000574.4
Refseq (protein) NP_000565.1
PubMed search 1604

Complement decay-accelerating factor (synonym CD55 , DAF , roughly translated as: ' Complement decay accelerating factor') is a surface protein from the complement system .

properties

CD55 binds C4b and C3b to the cell surface of neighboring cells. This prevents them from converting C2 to C2a and factor B to Bb, which prevents the formation of the protein complexes C4b2a and C3bBb. CD55 is produced by all cell types that are in contact with proteins of the complement system from the blood plasma . It is also formed by epithelial cells . It is glycosylated and has a GPI anchor . CD55 is part of the Cromer - blood group system .

CD55 is the cellular receptor for various viruses : Coxsackievirus A21, B1, B3 and B5 as well as human echovirus 6, 7, 11, 12, 20 and 21 and probably also human enterovirus 70 and D68. Uropathogenic E. coli bind to CD55.

A mutation in the CD55 is associated with an increased risk of non-small cell lung cancer .

Web links

Individual evidence

  1. ↑ OB Spiller, IG Goodfellow, DJ Evans, JW Almond, BP Morgan: Echoviruses and coxsackie B viruses that use human decay-accelerating factor (DAF) as a receptor do not bind the rodent analogues of DAF. In: The Journal of Infectious Diseases. Volume 181, Number 1, January 2000, pp. 340-343, doi : 10.1086 / 315210 , PMID 10608785 .
  2. ^ TM Karnauchow, DL Tolson, BA Harrison, E. Altman, DM Lublin, K. Dimock: The HeLa cell receptor for enterovirus 70 is decay-accelerating factor (CD55). In: Journal of virology. Volume 70, Number 8, August 1996, pp. 5143-5152, PMID 8764022 , PMC 190469 (free full text).
  3. ^ S. Lea: Interactions of CD55 with non-complement ligands. In: Biochemical Society transactions. Volume 30, Pt 6 November 2002, pp. 1014-1019, PMID 12440964 .
  4. ↑ Y. Zhang, Z. Zhang, L. Cao, J. Lin, Z. Yang, X. Zhang: A common CD55 rs2564978 variant is associated with the susceptibility of non-small cell lung cancer. In: Oncotarget. [Electronic publication before going to press] December 2016, doi : 10.18632 / oncotarget.14053 , PMID 28008159 .