Clostridium piliforme
| Clostridium piliforme | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Systematics | ||||||||||||
|
||||||||||||
| Scientific name | ||||||||||||
| Clostridium piliforme | ||||||||||||
| ( ex Tyzzer 1917) Duncan, Carman, Olsen & Wilson 1993 |
Clostridium piliforme is a spore-forming bacterium belonging to the genus Clostridia . It was discovered in 1917 by Ernest Edward Tyzzer (1875-1965) as the causative agent of a fatal disease in mice and classified as Bacillus piliformis . Based on molecular biological findings, it was proposed in 1993 to assign it to the clostridia. Thedisease causedby Clostridium piliform iscalled Tyzzer's Disease after its first descriptionand mainly affects rodents , but also other mammals. An individual case has also been described in humans.
Clostridium piliforme is an obligatory intracellular living bacterium and therefore cannot be grown in cell-free media. The pathogen can be detected by immunofluorescence , ELISA , Western blot or PCR .
Web links
- Information on Clostridium piliform Society for Laboratory Animal Science ( Memento from December 6, 2010 in the Internet Archive )
Individual evidence
- ^ EE Tyzzer (1917): A Fatal Disease of the Japanese Waltzing Mouse Caused by a Spore-bearing Bacillus (Bacillus piliformis). J Med Res (37), pp. 307-338.
- ^ AJ Duncan, RJ Carman, GJ Olsen and KH Wilson (1993): Assignment of the agent of Tyzzer's disease to Clostridium piliforme comb. nov. on the basis of 16S rRNA sequence analysis. Int. J. Syst: Bacteriol. (43), pp. 314-318.