Deoxyribonucleotides

Deoxyribonucleotides are the building blocks of deoxyribonucleic acid (DNA). Together with the ribonucleotides , they belong to the nucleotides . Deoxyribonucleotides consist of the sugar deoxyribose , which is linked to the nucleobases adenine  (A) and guanine  (G) ( purine base ) or cytosine  (C) and thymine (T) ( pyrimidine base ), as well as a phosphate residue , which leads to the deoxyribonucleotides dAMP, dGMP, dCMP and dTMP (deoxyribonucleoside monophosphate, dNMP).

At the 1'-carbon atom of the deoxyribose is the nucleobase is at the 2'-carbon atom, in contrast to ribose is a hydrogen atom (-H) of ribonucleotides instead of a hydroxy group (-OH), and at the 5-carbon atom of the phosphate residue. In the case of polymerization by enzymatic condensation to form DNA, a hydroxyl group of the phosphate radical binds to the 3'-hydroxyl group of the deoxyribose of the subsequent deoxyribose. Hence the convention of reading the DNA from the 5 'end to the 3' end .

literature

• Jeremy M. Berg, John L. Tymoczko, Lubert Stryer : Biochemie , 6th edition, Spectrum Akademischer Verlag, Heidelberg 2007, ISBN 978-3-8274-1800-5 .
• Donald Voet, Judith G. Voet: Biochemistry , 3rd Edition, John Wiley & Sons, New York 2004, ISBN 0-471-19350-X .
• Bruce Alberts , Alexander Johnson, Peter Walter, Julian Lewis, Martin Raff, Keith Roberts: Molecular Biology of the Cell , 5th Edition, Taylor & Francis 2007, ISBN 978-0-81534106-2 .