Dexibuprofen
Structural formula | ||||||||||||||||||||||
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General | ||||||||||||||||||||||
Non-proprietary name | Dexibuprofen | |||||||||||||||||||||
other names |
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Molecular formula | C 13 H 18 O 2 | |||||||||||||||||||||
Brief description |
white crystals |
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Drug information | ||||||||||||||||||||||
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properties | ||||||||||||||||||||||
Molar mass | 206.28 g mol −1 | |||||||||||||||||||||
Physical state |
firmly |
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Melting point |
49-53 ° C |
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solubility |
almost insoluble in water |
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safety instructions | ||||||||||||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Dexibuprofen is the ( S ) - enantiomer of the racemate ibuprofen , which was first patented in 1996. Dexibuprofen's like Ibuprofen, a cyclooxygenase - inhibitor , which as a drug ( non-steroidal anti ) is used.
Since it is supposed to be about twice as effective, you get by with a smaller amount of drug per tablet. In addition, the effect of this pain reliever sets in a little faster than the racemate ibuprofen.
Since the body's own 2-arylpropionyl-CoA-epimerase can racemize dexibuprofen to ibuprofen, the therapeutic advantages of dexibuprofen over ibuprofen are controversial. Dexibuprofen is said to cause fewer side effects, but this is also doubted by other studies.
Trade names
Deltaran (D), DexOptifen (CH), Dolomagon (D), Eu-Med neu (A), Monactil (A), Movone (A), Seractil (A, CH), Atriscal (A), as well as a generic (A )
Individual evidence
- ↑ a b c Data sheet dexibuprofen at Acros, accessed on February 20, 2010.
- ↑ Data sheet (S) - (+) - Ibuprofen from Sigma-Aldrich , accessed on March 24, 2011 ( PDF ).
- ^ Paul F. White (2003): Can the Use of Specific Isomers Improve the Safety and Efficacy of Nonsteroidal Antiinflammatory Drugs? In: Anesth Analg. 97 (2): pp. 309-310; PMID 12873909 .
- ^ Dexibuprofen , in: Pharmazeutische Zeitung Online , GOVI-Verlag.
- ↑ Seractil forte 400 mg - Instructions for use. Medicamio, accessed on March 10, 2017 (Austrian German).