Docusate sodium

Structural formula
	Simplified structural formula without stereochemistry
General
Non-proprietary name	Docusate sodium
other names	Sodium dioctyl sulfosuccinate; Dioctyl sodium sulfosuccinate; Bis-2-ethylhexyl sulfosuccinate; DIETHYLHEXYL SODIUM SULFOSUCCINATE ( INCI ) ;
Molecular formula	C 20 H 37 O 7 NaS
Brief description	colorless to white, waxy, plastic mass or flakes
External identifiers / databases
EC number	209-406-4
ECHA InfoCard	100.008.553
PubChem	23673837
Wikidata	Q2815334
Drug information
ATC code	A06 AA02
properties
Molar mass	444.56 g · mol -1
Physical state	firmly
density	1.146 g cm −3
Melting point	173-179 ° C
solubility	heavy in water (8.17 g l −1 at 20 ° C)
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances danger
H and P phrases	H: 315-318
	P: 280-305 + 351 + 338
Toxicological data	1,900 mg kg −1 ( LD 50 , rat , oral ) ; > 10,000 mg kg −1 ( LD 50 , rabbit , transdermal ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Docusate sodium is a surface-active substance that is used, for example, as a medicinal substance , as a pharmaceutical auxiliary or as a cosmetic ingredient.

Use in medicine

In medicine, docusate sodium is used as a laxative . After introduction into the rectum, for example as an enema or rectal gel, the reduction in interfacial tension causes an increase in the water content and thus a softening of the stool, which leads to a defecation stimulus and rapid emptying within 5 to 20 minutes . Areas of application are the symptomatic treatment of constipation ( constipation ) and the preparation of the colon and rectum for endoscopic examinations.

Docusate is also used to remove cerumen .

Technical use

The potassium analog of docusate sodium is contained in a lead substitute for classic car engines.

Individual evidence

↑ Entry on DIETHYLHEXYL SODIUM SULFOSUCCINATE in the CosIng database of the EU Commission, accessed on December 28, 2019.
↑ ^a ^b ^c ^d data sheet Docusate sodium salt, ≥99.0% (TLC) from Sigma-Aldrich , accessed on January 11, 2013 ( PDF ).
↑ ^a ^b ^c ^d Entry on sodium bis (2-ethylhexyl) sulfosuccinate in the GESTIS substance database of the IFA , accessed on January 8, 2018(JavaScript required) .
^ V. Fleming, WE Wade: A review of laxative therapies for treatment of chronic constipation in older adults. In: The American Journal of Geriatric Pharmacotherapy . Volume 8, Number 6, December 2010, pp. 514-550, doi : 10.1016 / S1543-5946 (10) 80003-0 . PMID 21356503 .
↑ MJ Burton, C. Doree: Ear drops for the removal of ear wax. In: The Cochrane database of systematic reviews. Number 1, 2009, S. CD004326, doi : 10.1002 / 14651858.CD004326.pub2 . PMID 19160236 .
↑ Safety data sheet - Castrol TBE. In: msdspds.castrol.com. Castrol , archived from the original on March 13, 2016 ; accessed on March 12, 2016 .

[CosIng-1] Entry on DIETHYLHEXYL SODIUM SULFOSUCCINATE in the CosIng database of the EU Commission, accessed on December 28, 2019.

[Sigma-2] ta sheet Docusate sodium salt, ≥99.0% (TLC) from Sigma-Aldrich , accessed on January 11, 2013 ( PDF ).

[GESTIS-3] Entry on sodium bis (2-ethylhexyl) sulfosuccinate in the GESTIS substance database of the IFA , accessed on January 8, 2018(JavaScript required) .

[4] V. Fleming, WE Wade: A review of laxative therapies for treatment of chronic constipation in older adults. In: The American Journal of Geriatric Pharmacotherapy . Volume 8, Number 6, December 2010, pp. 514-550, doi : 10.1016 / S1543-5946 (10) 80003-0 . PMID 21356503 .

[5] MJ Burton, C. Doree: Ear drops for the removal of ear wax. In: The Cochrane database of systematic reviews. Number 1, 2009, S. CD004326, doi : 10.1002 / 14651858.CD004326.pub2 . PMID 19160236 .

[6] Safety data sheet - Castrol TBE. In: msdspds.castrol.com. Castrol , archived from the original on March 13, 2016 ; accessed on March 12, 2016 .