Gliotoxin
Structural formula | ||||||||||||||||
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General | ||||||||||||||||
Surname | Gliotoxin | |||||||||||||||
other names |
Aspergillin |
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Molecular formula | C 13 H 14 N 2 O 4 S 2 | |||||||||||||||
Brief description |
white to yellow solid |
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External identifiers / databases | ||||||||||||||||
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properties | ||||||||||||||||
Molar mass | 326.4 g mol −1 | |||||||||||||||
Physical state |
firmly |
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Melting point |
200-202 ° C |
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safety instructions | ||||||||||||||||
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Toxicological data | ||||||||||||||||
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Gliotoxin is a potent mycotoxin (mold toxin ) that is produced by Aspergillus fumigatus , Aspergillus terreus , Eurotium chevalieri and Gliocladium fimbriatum . Since the toxin is primarily formed by the widespread Aspergillus fumigatus, organic waste could also contain increased amounts of this mycotoxin under suitable conditions.
effect
The effect of gliotoxin manifests itself primarily in its immunosuppressive and cytotoxic (cell-toxic) properties. The toxin accelerates natural cell death ( apoptosis ) in animal and human body cells, which usually only occurs after the cell has reached a certain age.
Gliotoxin is also of interest for medical research, as its cytotoxic effect has also been demonstrated in cancer cells . Gliotoxin may therefore also be used in cancer therapy .
Individual evidence
- ↑ a b Fermentec Biotechnology: Safety data sheet ( Memento of the original of September 27, 2007 in the Internet Archive ) Info: The archive link was automatically inserted and not yet checked. Please check the original and archive link according to the instructions and then remove this notice. .
- ↑ Fermentec Biotechnology: Description .
- ↑ a b Datasheet Gliotoxin from Gliocladium fimbriatum at Sigma-Aldrich , accessed on October 22, 2016 ( PDF ).