Glucosuria

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As glycosuria or glucosuria is defined as the increased excretion of glucose (glucose) through the urine by the kidneys . Urine glucose values ​​of 15 mg / dl (0.8 mmol / l) in the "fasting urine", that is about 15% of the normal blood sugar level , are still considered physiological . The values ​​of "non-fasting urine" can be up to twice as high due to food. However, if values ​​are measured in "fasting urine" that are greater than 15 mg / dl (0.8 mmol / l), this is referred to as glucosuria.

Glucosuria can be caused on the one hand by an increase in blood glucose concentration (e.g. in diabetes mellitus ) and thus exceeding the kidney threshold , on the other hand by a kidney dysfunction ( diabetes renalis or renal glucosuria). The genetically determined form of renal glucosuria is based on a mutation in the sodium / glucose cotransporter type 2 (SGLT2). It is to be assessed as harmless.

The kidney threshold is at an individual blood glucose concentration of approx. 140–170 mg / dl (7.7–9.35 mmol / l). From then on, not all filtered glucose molecules across the proximal tubule cells are reabsorbed the kidney, since the transport mechanism ( co-transport with sodium - ion ) is saturated. This also increases the number of particles in the urine and osmotic diuresis ensues .