Kyotorphin
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| Surname | Kyotorphin | ||||||||||||
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| Molecular formula | C 15 H 23 N 5 O 4 | ||||||||||||
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| Molar mass | 337.37 g · mol -1 | ||||||||||||
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| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | |||||||||||||
Kyotorphin ( L - Tyrosyl - L - Arginine ) is a neurophysiologically active dipeptide that plays a role in pain regulation in the brain . It was first isolated from bovine brains ( Bovinae ) by Japanese scientists in 1979 . It owes its name to the city of Kyoto , where it was discovered.
effect
Kyotorphin has an enkephalin- and morphine-like analgesic effect. However, it does not interact with the opioid receptors . It uses Opiodpeptid , Met- enkephalin , free and stabilize it against its degradation. It may also have the properties of neurotransmitters , neuromediators, or neuromodulators . Kyotorphin has been shown to be found in human cerebrospinal fluid and to be less present in patients with persistent pain.
See also
literature
- Takagi H. et al. (1979): A novel analgesic dipeptide from bovine brain is a possible met-enkephalin releaser. Nature (London) 282: 410-412; PMID 228202 .
- Nishimura K. et al. (1991): Kyotorphin like substance in human cerebrospinal fluid of patients with persistent pain Masui . Nov; 40 (11): 1686-90; PMID 1766121 .
Individual evidence
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.