MUPS

from Wikipedia, the free encyclopedia

MUPS stands for Multiple Unit Pellet System; a dosage form that is made up of several pellets, some of which release differently, and auxiliary substances for tableting. Typically, MUPS formulations are put on the market in the form of tablets.

Composition and mechanism of operation

A MUPS tablet consists of pellets, which are pressed together with powdered auxiliary materials ( disintegrants , fillers). The pellets used are usually individually coated in order to determine the location, speed and time of the release of the active ingredient. Instead of coated pellets, matrix and multilayer pellets can also be used.

In the stomach, the tablet disintegrates into the individual pellets due to the digestive secretion ("gastric juice") present there. Due to their small diameter , the pellets can pass through the stomach gate regardless of food intake or filling volume. Solid components can only leave the stomach with a particle size smaller than 2 mm during the physiological digestion process. Larger particles - such as enteric-coated tablets that do not disintegrate in gastric juice - can only leave the stomach after it has been completely emptied. This may mean that the medicine takes several hours to take effect.

In the case of coated pellets, after possible damage to the coating, in contrast to coated conventional tablet formulations, there is no immediate release of the entire active ingredient, which is known as "dose dumping". Consequently, the risk of toxic effects due to overdose is avoided.

Due to the different coating possibilities of the individual pellets and their mixture, it is possible to process pellets with different release kinetics in one drug form. In addition, this also enables incompatible drugs to be mixed with one another. For this purpose, the pellets can consist of different layers, each layer containing different drugs.

The individual pellets are exposed to high mechanical loads during tableting, which is why the coatings should be particularly flexible. Eudragit NE® is an example of such a coating on a sustained release form.

The disadvantage of MUPS is the high production costs.

literature

  • P. Vaupel, H.-G. Schaible, E. Mutschler: anatomy, physiology, pathophysiology of humans. 7th edition, Wissenschaftliche Verlagsgesellschaft, Stuttgart 2015, ISBN 3-8047-2979-7 .
  • Alfred Fahr : Voigt Pharmaceutical Technology. 12th edition, Deutscher Apotheker Verlag, Stuttgart 2015, ISBN 978-3-7692-6194-3 .
  • K.-H. Bauer, K.-H. Fromming, C. Fuehrer: Pharmaceutical Technology. 10th edition, Wissenschaftliche Verlagsgesellschaft, Stuttgart 2017, ISBN 978-3-8047-3268-1 .

Individual evidence

  1. ↑ P. Vaupel, H.-G. Schaible, E. Mutschler: anatomy, physiology, pathophysiology of humans. 7th edition, Wissenschaftliche Verlagsgesellschaft, Stuttgart 2015, ISBN 3-8047-2979-7 .