Nafamostat

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Structural formula
Structural formula of nafamostat
General
Non-proprietary name Nafamostat
other names
  • 6-amidino-2-naphthyl p-guanidinobenzoate
  • 4-guanidinobenzoic acid 6-amidino-2-naphthyl ester
Molecular formula C 19 H 17 N 5 O 2
External identifiers / databases
CAS number 81525-10-2
PubChem 4413
ChemSpider 4260
DrugBank DB12598
Wikidata Q15409374
Drug information
Drug class

Protease inhibitors

Mechanism of action

Antifibrinolytic

properties
Molar mass 347.37 g mol
safety instructions
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Nafamostat is a synthetically produced active ingredient from the group of protease inhibitors . It was introduced to the market in Japan in 1986 as Futhan for the parenteral treatment of the acute symptoms of pancreatitis ( pancreatitis ) and for use in certain bleeding complications ( disseminated intravascular coagulopathy , prevention of coagulation during hemodialysis in patients with bleeding lesions or bleeding tendencies during extravascular circulation ).

Chemically Nafamostat a derivative ( derivative ) of the p -aminobenzoic acid . The active ingredient is used medicinally as nafamostat mesilate , i.e. the salt of methanesulfonic acid .

Nafamostat is a potential candidate for the therapy of Covid-19 .

See also

Camostat

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  2. ↑ Torii Pharmaceutical Co., Ltd, Trangsfer Marketing Notice , February 2019 ( PDF ), accessed March 30, 2020.
  3. ↑ External identifiers or database links to camostat mesilate : CAS number: 82956-11-4, EC number: 692-168-2, ECHA InfoCard: 100.220.175 , PubChem : 5311180 , ChemSpider : 49623 , Wikidata : Q27252259 . UNII: 1D2T74921W . Other names: FUT-175.
  4. ↑ Monograph Nafamostat Mesilate , Japanese Pharmacopoeia (JP) 17, p. 156 f. ( PDF , 4.4 MB).
  5. ↑ Remdesivir: Ebola drug against Covid-19? , apotheke adhoc, March 13, 2020.