Rowena Green Matthews
Rowena Margaret Green Matthews (born August 20, 1938 in Cambridge , England ) is an American biochemist and biophysicist .
Life
Rowena Green Matthews was born in Cambridge in 1938, the first-born daughter of David E. Green and Doris Cribb. Her father, who was from the United States , was a biochemist at the University of Cambridge , where he received his PhD in 1934, and her Cambridge-born mother was the director of the design department at the Cambridge School of Art . In 1940 the family moved to the USA. She spent most of her youth in New York City and Madison , Wisconsin , where her father worked from 1948 at the University of Wisconsin – Madison for 35 years.
In 1956 she went to Radcliffe College in Cambridge , Massachusetts , where she made her bachelor's degree in biology in 1960 . She then worked for a few years at Harvard University in the laboratory of George Wald , who, together with Ragnar Granit and Haldan Keffer Hartline, received the Nobel Prize in Physiology or Medicine in 1967 for studying the physiological and chemical processes in the eye , which made her embark on an academic career animated. In 1965 she went to the University of Michigan , where she in 1969 Biophysics with the work Free and complexed forms of old yellow enzymes: Their physical and catalytic properties doctorate .
Rowena Green Matthews later got a post-doctoral position in the Department of Biological Chemistry at the University of Michigan Medical School, where she later became a professor and earned the title of G. Robert Greenberg Distinguished University Professor of Biological Chemistry in 1995 . She was also Professor of Chemistry at the University's College of Literature, Science, and the Arts (LSA); today professor emeritus . In her research, she examined the mechanisms of enzymes that use folic acid and cobalamine as cofactors as well as the function of methylene tetrahydrofolate reductase (MTHFR) and identified the MTHFR-producing gene with her colleagues . Martha L. Ludwig's laboratory was involved in the crystal structure analysis of MTHFR .
Rowena Green Matthews is married to the orthopedic surgeon Larry Matthews, with whom she has two children. Her niece, Tammy Baldwin , has been a US Senator from Wisconsin since 2013 .
Awards (selection)
- 2000: William C. Rose Award (American Society for Biochemistry and Molecular Biology)
- 2001: Repligen Corporation Award in the Chemistry of Biological Processes ( American Chemical Society , ACS)
- 2002: Member of the National Academy of Sciences
- 2005: Member of the American Academy of Arts and Sciences
- 2009: Member of the American Philosophical Society
Publications (selection)
- RG Matthews, R. Hubbard, PK Brown, G. Wald: Tautomeric Forms of Metarhodopsin. In: The Journal of General Physiology. Vol. 47, No. 2, 1963, pp. 215-240, doi : 10.1085 / jgp.47.2.215 .
- C. Thorpe, RG Matthews, CH Williams Jr .: Acyl-coenzyme A dehydrogenase from pig kidney. Purification and properties. In: Biochemistry. Vol. 18, No. 2, 1979, pp. 331-337, doi : 10.1021 / bi00569a016 .
- CL Drennan, S. Huang, JT Drummond, RG Matthews, ML Ludwig : How a protein binds B12: A 3.0 A X-ray structure of B12-binding domains of methionine synthase. In: Science. Vol. 266, No. 5191, 1994, pp. 1669-1674, doi : 10.1126 / science.7992050 .
- P. Frosst, HJ Blom, R. Milos, P. Goyette, CA Sheppard, RG Matthews, GJH Boers, M. den Heijer, LAJ Kluijtmans, LP van den Heuvel, R. Rozen: A candidate genetic risk factor for vascular disease: A common mutation at the methylene tetrahydrofolate reductase locus. In: Nature Genetics. Vol. 10, 1995, pp. 111-113.
- BD Guenther, CA Sheppard, P. Tran, R. Rozen, RG Matthews, ML Ludwig: The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia. In: Nature Structural & Molecular Biology. Vol. 6, 1999, pp. 359-365, doi : 10.1038 / 7594 .
- K. Yamada, Z. Chen, R. Rozen, RG Matthews: Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase. In: PNAS. Vol. 98, No. 26, 2001, pp. 14853-14858, doi : 10.1073 / pnas.261469998 .
literature
- Rowena G. Matthews: A Love Affair with Vitamins. In: The Journal of Biological Chemistry. Vol. 284, No. 39, 2009, pp. 26217-26228, doi : 10.1074 / jbc.X109.041178 .
Web links
- Rowena Matthews, Ph.D. Department of Biological Chemistry, University of Michigan Medical School. Retrieved July 16, 2014.
Individual evidence
- ↑ Andrea Kovacs Henderson: American men & women of science (Volume 5). 26th edition, Thomson / Gale, Detroit 2009, ISBN 978-1414433059 , p. 282.
- ↑ Helmut Beinert, Paul K. Stumpf, Salih J. Wakil: DAVID EZRA GREEN 1910–1983. In: Biographical Memoirs. Vol. 84, 2003, pp. 112-145, here pp. 114-116.
- ^ A b c Rowena G. Matthews: A Love Affair with Vitamins. In: The Journal of Biological Chemistry. Vol. 284, No. 39, 2009, pp. 26217-26228, doi : 10.1074 / jbc.X109.041178 .
- ↑ a b Structural Enzymology: A Symposium Honoring Dr. Rowena E. Matthews. ( Memento of March 4, 2016 on the Internet Archive ) University of Michigan, May 18-19. May 2007.
- ^ William C. Rose Award. American Society for Biochemistry and Molecular Biology, ASBMB. Retrieved July 16, 2014.
- ^ Winner of the Repligen Corporation Award in the Chemistry of Biological Processes. American Chemical Society, Division of Biological Chemistry. Retrieved July 16, 2014.
- ^ Rowena G. Matthews, University of Michigan. National Academy of Sciences, Members. Retrieved July 16, 2014.
- ^ Book of Members, Chapter M. American Academy of Arts & Sciences, p. 363. Retrieved July 16, 2014.
- ^ Member History: Rowena G. Matthews. American Philosophical Society, accessed November 23, 2018 .
personal data | |
---|---|
SURNAME | Matthews, Rowena Green |
ALTERNATIVE NAMES | Matthews, Rowena Margaret Green |
BRIEF DESCRIPTION | American biochemist and biophysicist |
DATE OF BIRTH | August 20, 1938 |
PLACE OF BIRTH | Cambridge |