Deoxythymidine

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Structural formula
Structural formula of deoxythymidine
General
Surname Deoxythymidine
other names
  • 1- (2-Deoxy- β - D -ribofuranosyl) thymine
  • 1- (2-Deoxy- β - D -ribofuranosyl) -5-methyluracil
  • Thymine 2'-deoxyriboside
  • 1 - [(2 R , 4 S , 5 R ) -4-hydroxy-5- (hydroxymethyl) oxolan-2-yl] -5-methylpyrimidin-2,4-dione
  • Abbreviation dT or dThd
Molecular formula C 10 H 14 N 2 O 5
Brief description

colorless platelets or needles

External identifiers / databases
CAS number 50-89-5
EC number 200-070-4
ECHA InfoCard 100,000,065
PubChem 5789
ChemSpider 5585
DrugBank DB04485
Wikidata Q422464
properties
Molar mass 242.23 g mol −1
Physical state

firmly

Melting point

188 ° C

solubility
safety instructions
GHS labeling of hazardous substances
no GHS pictograms
H and P phrases H: no H-phrases
P: no P-phrases
Toxicological data

2,512 mg kg −1 ( LD 50 ,  mouse ,  ip )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Deoxythymidine ( dT ) is selected from the nucleobase thymine and the pentose D -Desoxyribose constructed nucleoside , as the common constituent of deoxyribonucleic acid occurs (DNA).

It is often called thymidine for short with the older trivial name, which is still in use , but should not be confused with ribothymidine , the nucleoside made up of thymine and ribose, which occurs as a rare component of ribonucleic acid (RNA), for example in tRNA molecules.

The thymine contained in deoxythymidine forms a base pair with the nucleoside adenine of the nucleoside deoxyadenosine (dA) in a double strand of DNA .

The nucleobases adenine (A) and thymine (T) form a base pair via two hydrogen bonds

Isomers and analogs

Individual evidence

  1. ↑ a b c d Entry on thymidine. In: Römpp Online . Georg Thieme Verlag, accessed December 10, 2014.
  2. ↑ a b c Data sheet Thymidine, ≥99% from Sigma-Aldrich , accessed on February 13, 2013 ( PDF ).
  3. ↑ Glossary entry on thymidine at Chemgapedia .
  4. ↑ Löffler, Petrides, Heinrich: Biochemie & Pathobiochemie , 8th edition (2007), Springer, Heidelberg.

Web links

Wikibooks: Biochemistry and Pathobiochemistry: Pyrimidine Metabolism  - Learning and Teaching Materials
Commons : Thymidine  - Collection of pictures, videos and audio files
  • Entry for thymidines in the Human Metabolome Database (HMDB) , accessed October 12, 2013.