Ganglioneuroblastoma

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Classification according to ICD-10
C47 Malignant neoplasm: peripheral nerves and autonomic nervous system,
C47.1 Peripheral nerves of the upper extremity, including the shoulder
C47.2 Peripheral nerves of the lower extremity, including the hip
C47.3 Peripheral nerves of the thorax
C47.3 Peripheral nerves of the abdomen
C47.5 Peripheral nerves of the pelvis
C47.9 not further described
ICD-10 online (WHO version 2019)
Classification according to ICD-O-3
9490/3 Ganglioneuroblastoma
ICD-O-3 first revision online
Ganglioneuroblastoma histology

The ganglioneuroblastoma (formerly also known as malignant ganglioneuroma ) is a rare tumor of the nervous system, the differentiation of which is to be classified between neuroblastoma and ganglioneuroma. Most tumors are located in the trunk, especially in the retroperitoneal space along the sympathetic ganglia on both sides of the spine or the posterior mediastinum . The tumors can often calcify.

morphology

A distinction is made between two forms: the Schwannzell-stroma-rich (imperfect) variant with all levels of neuronal differentiation, and the mixed form of Schwann-cell-stroma-rich and Schwann-cell-stroma-poor parts, or immature variant. The latter variant has a slightly poorer clinical prognosis.

Differential diagnosis

In particular, the tumor must be differentiated from the differentiating neuroblastomas.

further reading

  • K. Koike, M. Iihara et al. a .: Adult-type ganglioneuroblastoma in the adrenal gland treated by a laparoscopic resection: report of a case. In: Surgery today. Volume 33, Number 10, 2003, pp. 785-790, ISSN  0941-1291 . doi : 10.1007 / s00595-003-2565-8 . PMID 14513331 . (Review).
  • GJ Lonergan, CM Schwab u. a .: Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. In: Radiographics. Volume 22, Number 4, 2002 Jul-Aug, pp. 911-934, ISSN  0271-5333 . PMID 12110723 . (Review).

Individual evidence

  1. ↑ C. Aoyama, SJ Qualman et al. a .: Histopathologic features of composite ganglioneuroblastoma. Immunohistochemical distinction of the stromal component is related to prognosis. In: Cancer . Volume 65, Number 2, January 1990, pp. 255-264, ISSN  0008-543X . PMID 2295048 .