Keratoacanthoma
| Classification according to ICD-10 | |
|---|---|
| L85.8 | Keratoacanthoma |
| ICD-10 online (WHO version 2019) | |
The keratoacanthoma is a fast growing benign usually skin tumor that can regress spontaneously untreated. For some authors, however, keratoacanthoma is a variant of squamous cell carcinoma with a particularly favorable prognosis. Since the histopathological criteria for differentiating between keratoacanthoma and squamous cell carcinoma are imprecise, a clear assignment is not always possible.
pathology
The tumor grows nodularly from the keratinocytes of the hair follicle funnel and forms a central horn cone in the middle, a so-called keratotic plug . This is surrounded by the surrounding epithelium like a lip.
histology
The lower edge of the epithelium is less rich in mitosis than in squamous cell carcinoma, irregular and interspersed with an inflammatory infiltrate , so the tumor is histologically similar to squamous cell carcinoma (especially with the highly differentiated spinalioma), which is why it is classified as a pseudocancerous disease. In addition, a keratoacanthoma can turn into a spinalioma at a later stage, i.e. transform it malignantly.
Occur
Keratoacanthomas are mainly observed in older people. They mainly occur in areas exposed to light. Its cause is still unknown today.
therapy
Because it is difficult to distinguish it from keratinizing squamous cell carcinoma and because the possibility of malignant transformation cannot be ruled out, early surgical removal of keratoacanthomas is recommended.
swell
- U.N. Riede (ed.): General and special pathology. Thieme, Stuttgart 1993, ISBN 3-13-683303-9 , p. 937.
- Ingrid Moll (Ed.): Dermatology. 6th edition. Thieme, Stuttgart 2005, ISBN 3-13-126686-4 , p. 343.
- N. Misago et al .: Keratoacanthoma and other types of squamous cell carcinoma with crateriform architecture: classification and identification. In: Journal of Dermatology. 2013 Jun; 40 (6), pp. 443–452.
- CL Kane et al .: Histopathology of cutaneous squamous cell carcinoma and its variants. In: Seminars in Cutaneous Medicine and Surgery . 2004 Mar; 23 (1), pp. 54-61.
