Schematic representation of the different types of membrane-bound proteins: 1) Interaction through an amphipathic α-helix parallel to the membrane plane. 2) interaction through a hydrophobic loop. 3) Interaction by binding to membrane lipids. 4) Electrostatic or ionic interaction with membrane lipids (e.g. via calcium ions).
As a membrane-bound proteins are called proteins , while in a biomembrane are anchored, but they are not cross and hence localized on one side of the membrane. They belong to the class of peripheral membrane proteins.