Microsomal ethanol oxidizing system

The microsomal ethanol-oxidizing system (MEOS) is a method of ethanol metabolism in the liver cells that is independent of alcohol dehydrogenase .

It was first described by Lieber and DeCarli in 1968. With chronic alcohol consumption, the MEOS is induced and breaks down alcohol in addition to the original alcohol dehydrogenase. This makes it a basic mechanism for developing tolerance towards the substance. The activity of the MEOS is associated with an activation of the cytochrome P450 2E1 . The MEOS and the cytochromes induced by it can also reduce the metabolism of other substances or shift them to toxic metabolites. This explains, for example, adverse drug reactions in chronic alcohol addicts. In addition, the MEOS interferes with the lipid metabolism of the liver cells and is also seen as a cause of the development of fatty liver .

Individual evidence

^ ^A ^b Charles S. Lieber: Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998) - a review . In: Alcoholism, Clinical and Experimental Research . tape 23 , no. 6 , June 1999, ISSN 0145-6008 , p. 991-1007 , doi : 10.1111 / j.1530-0277.1999.tb04217.x , PMID 10397283 .
^ R. Moreno Otero, JR Cortés: [Nutrition and chronic alcohol abuse] . In: Nutricion Hospitalaria . tape 23 , Suppl 2, May 2008, ISSN 0212-1611 , p. 3-7 , PMID 18714405 (Spanish, scielo.isciii.es ).

[lieber-1] A ^b Charles S. Lieber: Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998) - a review . In: Alcoholism, Clinical and Experimental Research . tape 23 , no. 6 , June 1999, ISSN 0145-6008 , p. 991-1007 , doi : 10.1111 / j.1530-0277.1999.tb04217.x , PMID 10397283 .

[2] R. Moreno Otero, JR Cortés: [Nutrition and chronic alcohol abuse] . In: Nutricion Hospitalaria . tape 23 , Suppl 2, May 2008, ISSN 0212-1611 , p. 3-7 , PMID 18714405 (Spanish, scielo.isciii.es ).