Pérez de Guzmán
Pérez de Guzmán is a family name that may refer to:
- Alonso Pérez de Guzmán (1550–1615), Spanish grandee and commander of the Spanish Armada
- Domingo Pérez de Guzmán y Silva (1691–1739), Spanish nobleman, Count of Niebla, Duke of Medina-Sidonia, Marquis of Cazaza
- Fernán Pérez de Guzmán (around 1377 – around 1460), Spanish writer