Cytomegalovirus vaccine

A cytomegalovirus vaccine (synonymous CMV vaccine ) is a vaccine against the cytomegalovirus (CMV).

properties

So far (2015) there are no approved cytomegalovirus vaccines. Cytomegaloviruses belong to the TORCH complex ( toxoplasmosis , other, rubella , cytomegalovirus, herpes simplex virus-2 or herpes neonatorum ), which includes infectious diseases that can be vertically transmitted from mother to child. The experimental cytomegalovirus vaccines will be used to reduce vertical transmission from mother to child and to people with immunosuppression , for whom reactivation of cytomegalovirus can generally lead to complications. Cytomegalovirus vaccines are designed to protect against infection or reactivation .

The experimental approaches include recombinant proteins , attenuated cytomegaloviruses and DNA vaccines . The antigens investigated include the viral proteins gB and pp65 and the pentameric protein complex gH / gL-PC from gH , gL , UL128 , UL130 and UL131A .

Individual evidence

^ S. Plotkin: The history of vaccination against cytomegalovirus. In: Medical microbiology and immunology. Volume 204, number 3, June 2015, pp. 247-254, doi : 10.1007 / s00430-015-0388-z , PMID 25791890 .
↑ ^a ^b A. E. Lilja, PW Mason: The next generation recombinant human cytomegalovirus vaccine candidates-beyond gB. In: Vaccine. Volume 30, Number 49, November 2012, pp. 6980-6990, doi : 10.1016 / j.vaccine.2012.09.056 , PMID 23041121 .
^ V. Dasari, C. Smith, R. Khanna: Recent advances in designing an effective vaccine to prevent cytomegalovirus-associated clinical diseases. In: Expert review of vaccines. Volume 12, number 6, June 2013, pp. 661-676, doi : 10.1586 / erv.13.46 , PMID 23750795 .
↑ F. Wussow, F. Chiuppesi, J. Martinez, J. Campo, E. Johnson, C. Flechsig, M. Newell, E. Tran, J. Ortiz, C. La Rosa, A. Herrmann, J. Longmate, R. Chakraborty, PA Barry, DJ Diamond: Human cytomegalovirus vaccine based on the envelope gH / gL pentamer complex. In: PLoS pathogens. Volume 10, number 11, November 2014, p. E1004524, doi : 10.1371 / journal.ppat.1004524 , PMID 25412505 , PMC 4239111 (free full text).

[1] S. Plotkin: The history of vaccination against cytomegalovirus. In: Medical microbiology and immunology. Volume 204, number 3, June 2015, pp. 247-254, doi : 10.1007 / s00430-015-0388-z , PMID 25791890 .

[PMID_23041121-2] A. E. Lilja, PW Mason: The next generation recombinant human cytomegalovirus vaccine candidates-beyond gB. In: Vaccine. Volume 30, Number 49, November 2012, pp. 6980-6990, doi : 10.1016 / j.vaccine.2012.09.056 , PMID 23041121 .

[3] V. Dasari, C. Smith, R. Khanna: Recent advances in designing an effective vaccine to prevent cytomegalovirus-associated clinical diseases. In: Expert review of vaccines. Volume 12, number 6, June 2013, pp. 661-676, doi : 10.1586 / erv.13.46 , PMID 23750795 .

[4] F. Wussow, F. Chiuppesi, J. Martinez, J. Campo, E. Johnson, C. Flechsig, M. Newell, E. Tran, J. Ortiz, C. La Rosa, A. Herrmann, J. Longmate, R. Chakraborty, PA Barry, DJ Diamond: Human cytomegalovirus vaccine based on the envelope gH / gL pentamer complex. In: PLoS pathogens. Volume 10, number 11, November 2014, p. E1004524, doi : 10.1371 / journal.ppat.1004524 , PMID 25412505 , PMC 4239111 (free full text).