Baboon syndrome

from Wikipedia, the free encyclopedia
Classification according to ICD-10
L24.4 Toxic contact dermatitis from drugs or medicinal products on skin contact
L25.1 Unspecified contact dermatitis caused by drugs or medication by skin contact
ICD-10 online (WHO version 2019)

As a baboon syndrome ( English baboon , baboon '; the literal translation baboon syndrome has in the German speaking little established), also called SDRIFE abbreviated (Engl. S ymmetric d rug- r elated i ntertriginous and f lexural e xanthema , symmetrical drug-conditional intertriginous and flexurales rash ') is called a drug eruption , which is characterized by a red color of the skin on the buttocks , the genitalia manifested and flexures.

The naturally red gluteal region in baboons gave the name to Baboon Syndrome in humans.

description

Baboon syndrome is triggered by the systemic ingestion of a substance, usually a drug. The classic contact allergens are excluded. After the allergen has been absorbed, skin reddening ( erythema ) forms in the area of ​​the buttocks or the perianal region and / or V-shaped in the area of ​​the groin (inguinae). The erythema is bilateral or symmetrical and at least one other flexure is affected. There are no systemic symptoms .

frequency

Between the first description in 1984 and 2011, around 100 cases were known worldwide. Baboon syndrome is therefore extremely rare.

Causes and pathology

The substances that can trigger Baboon syndrome include ampicillin and amoxicillin , mesalazine , metallic nickel and mercury or their compounds, iodine- containing contrast media , heparin , allopurinol , omeprazole , cetuximab and terbinafine .

The skin reaction does not manifest itself until several hours (up to 72 hours) after the administration of the allergy-causing substance.

The pathomechanism is a hematogenously mediated (spread via the blood vessel system ) contact allergy of cell-mediated type IV .

Differential diagnosis

In the differential diagnosis , intertrigo , anal eczema , mycoses , systemic contact dermatitis , initial staphylococcal scalded skin syndrome (SSSS) and toxic shock syndrome (TSS) must be distinguished from Baboon syndrome .

treatment

Baboon syndrome is basically a benign disease. The erythema usually disappears one to two weeks after the last contact with the triggering allergen. So far, no cases have been reported in which the redness or any part of it has remained. Topical use of corticosteroids can relieve symptoms in severe cases.

Initial description

Baboon syndrome was first described in 1984 by the Danish dermatologists Klaus Ejner Andersen , Niels Hjorth and Torkil Menné from Odense University Hospital .

further reading

Individual evidence

  1. ↑ a b E. E. Küng: Clinic and trigger of cutaneous drug syndromes. ( Memento of the original from March 4, 2016 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. (PDF; 388 kB) @1@ 2Template: Webachiv / IABot / www.hautzone.ch
  2. ↑ G. Allain-Veyrac, A. Lebreton et al. a .: First case of symmetric drug-related intertriginous and flexural exanthema (sdrife) due to rivastigmine? In: American Journal of Clinical Dermatology . Volume 12, Number 3, June 2011, pp. 210-213, doi : 10.2165 / 11318350-000000000-00000 . PMID 21469764 . (Review).
  3. ^ LP Rasmussen, T. Menné: [Systemic contact eczema - the baboon syndrome - in ampicillin allergy]. In: Ugeskr Laeg. Volume 147, Number 16, April 1985, pp. 1341-1342, PMID 3159140 .
  4. ↑ G. Kick, B. Przybilla: Delayed prick test reaction identifies amoxicillin as elicitor of baboon syndrome. In: Contact Dermatitis . Volume 43, Number 6, December 2000, pp. 366-367, PMID 11140395 .
  5. ^ C. Strub, AJ Bircher: Flexure-stressed rash ten hours after taking amoxicillin, "Baboon syndrome". In: Practice. Volume 91, Number 6, February 2002, pp. 232-234, PMID 11875845 .
  6. ^ R. Gallo, A. Parodi: Baboon syndrome from 5-aminosalicylic acid. In: Contact Dermatitis. Volume 46, Number 2, February 2002, p. 110, PMID 11918607 .
  7. ↑ T. Kolodziej, JC Szepietowski u. a .: The baboon syndrome due to nickel. In: Acta Dermatovenerol Croat. Volume 11, Number 1, 2003, pp. 29-31, PMID 12718793 .
  8. ↑ M. Lerch, AJ Bircher: Systemically induced allergic exanthem from mercury. In: Contact Dermatitis. Volume 50, Number 6, June 2004, pp. 349-353, doi : 10.1111 / j.0105-1873.2004.00366.x . PMID 15274725 .
  9. ↑ L. Wen, J. Yin et al. a .: Baboon syndrome induced by mercury - first case report in China. In: Contact Dermatitis. Volume 56, Number 6, June 2007, pp. 356-357, doi : 10.1111 / j.1600-0536.2006.01039.x . PMID 17577379 .
  10. ↑ CJ Le Coz, V. Boos et al. a .: An unusual case of mercurial baboon syndrome. In: Contact Dermatitis. Volume 35, Number 2, August 1996, p. 112, PMID 8917837 .
  11. ↑ L. Fernandez, E. Maquiera et al. a .: Baboon syndrome due to mercury sensitivity. In: Contact Dermatitis. Volume 33, Number 1, July 1995, pp. 56-57, PMID 7493470 .
  12. ↑ a b A. W. Arnold, P. Hausermann u. a .: Recurrent flexural exanthema (SDRIFE or baboon syndrome) after administration of two different iodinated radio contrast media. In: Dermatology . Volume 214, number 1, 2007, pp. 89-93, doi : 10.1159 / 000096920 . PMID 17191055 .
  13. ↑ SH Kardaun, RA Tupker: Symmetrical drug-related intertriginous and flexural exanthema (Baboon syndrome) induced by omeprazole. In: International Journal of Dermatology . [electronic publication before going to press] April 2011, doi : 10.1111 / j.1365-4632.2010.04689.x . PMID 21470217 .
  14. ↑ V. Sans, T. Jouary et al. a .: Baboon syndrome induced by cetuximab. In: Archives of Dermatology . Volume 144, Number 2, February 2008, pp. 272-274, doi : 10.1001 / archdermatol.2007.57 . PMID 18283197 .
  15. ↑ a b J. M. Weiss, M. Mockenhaupt u. a .: Fixed drug eruption on terbinafine with the characteristic distribution pattern of Baboon syndrome. In: The dermatologist . Volume 52, Number 12, December 2001, pp. 1104-1106, PMID 11910862 .
  16. ↑ R. Treudler, JC Simon: diagnosis of cutaneous drug allergy.  ( Page no longer available , search in web archives )  Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice. (PDF; 121 kB) In: Ärzteblatt Sachsen. Number 4, 2007, pp. 181-184.@1@ 2Template: Toter Link / www.slaek.de  
  17. ↑ A. Miyahara, H. Kawashima et al. a .: A new proposal for a clinical-oriented subclassification of baboon syndrome and a review of baboon syndrome. In: Asian Pac. J. Allergy Immunol. Volume 29, Number 2, June 2011, pp. 150-160, PMID 21980830 . (Review).
  18. ↑ KE Andersen, N. Hjorth, T. Menné: The baboon syndrome: systemically-induced allergic contact dermatitis. In: Contact Dermatitis. Volume 10, Number 2, February 1984, pp. 97-100, PMID 6232098 .

Web links