Cryptococcus

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Cryptococcus
Cryptococcus neoformans

Cryptococcus neoformans

Systematics
Department : Stand mushrooms (Basidiomycota)
Subdivision : Agaricomycotina
Class : Tremellomycetes
Order : Filobasidiales
Family : Filobasidiaceae
Genre : Cryptococcus
Scientific name
Cryptococcus
Vuill.

Cryptococcus is a genus of widespread yeast from the Filobasidiaceae family. Cryptococci , as the German name is, form round, 3–6 micrometer- sized sprout cells. The genus includes the cryptococcosis pathogens Cryptococcus neoformans , Cryptococcus gattii and Cryptococcus bacillisporus .

Cryptococcus is a genus that includes the anamorphic (only asexually reproducing) forms of the genus Filobasidiella . Representatives whose teleomorphic (sexual) form does not belong to Filobasidiella are now placed in other genera.

Cryptococcus is the world's most common causative agent of invasive fungal infections , collectively known as cryptococcosis , and is associated with one of the highest mortality rates . Cryptococcal infections that require treatment are treated with antimycotics (in particular fluconazole , amphotericin B , 5-flucytosine or itraconazole ). Every year, an estimated one million people worldwide develop cryptococcal meningitis , of which 625,000 patients die from it. Cryptococci are the most common pathogen causing meningitis in sub-Saharan Africa .

Types (selection)

There are 70 recognized species, and not all of them cause cryptococcosis.

swell

Individual evidence

  1. ^ Marianne Abele-Horn: Antimicrobial Therapy. Decision support for the treatment and prophylaxis of infectious diseases. With the collaboration of Werner Heinz, Hartwig Klinker, Johann Schurz and August Stich, 2nd, revised and expanded edition. Peter Wiehl, Marburg 2009, ISBN 978-3-927219-14-4 , p. 283 f.
  2. Jeremy N. Day, Tran TH Chau, Marcel Wolbers, Pham P. Mai, Nguyen T. Dung, Nguyen H. Mai, Nguyen H. Phu, Ho D. Nghia, Nguyen D. Phong, Cao Q. Thai, Le H. Thai, Ly V. Chuong, Dinh X. Sinh, Van A. Duong, Thu N. Hoang, Pham T. Diep, James I. Campbell, Tran PM Sieu, Stephen G. Baker, Nguyen VV Chau, Tran T. Hien , David G. Lalloo, Jeremy J. Farrar: Combination Antifungal Therapy for Cryptococcal Meningitis . New England Journal of Medicine 2013, Volume 368, Issue 14 April 4, 2013, pages 1291-1302, doi : 10.1056 / NEJMoa1110404 .
  3. Álvaro Fonseca, Teun Boekhout, Jack W. Fell: Chapter 138: Cryptococcus Vuillemin (1901), in: Cletus Kurtzman, JW Fell, Teun Boekhout (eds.): " The Yeasts A Taxonomic Study, Volume 1 "; Elsevier, BV 2010: p. 1661 ff .; ISBN 978-0-444-52149-1 . On-line