Galactose-1-phosphate

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Structural formula
Structural formula of galactose-1-phosphate
α- anomer of D- galactose-1-phosphate ( pyranose form )
General
Surname Galactose-1-phosphate
other names

G1P

Molecular formula C 6 H 13 O 9 P
External identifiers / databases
CAS number 2255-14-3
PubChem 123912
ChemSpider 110443
DrugBank DB02317
Wikidata Q3082858
properties
Molar mass 260.14 g mol −1
safety instructions
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Galactose-1-phosphate is a phosphoric acid ester of galactose . It is an intermediate in the provision of galactose for carbohydrate metabolism . Physiologically, only the D isomer plays a role.

Reactions

Galactose-1-phosphate is an intermediate in the provision of D- galactose for metabolism . It is released in addition to D- glucose after the breakdown of milk sugar ( lactose ) . For further use it must first be converted into its C4 epimer glucose . This is achieved by a galactokinase (GK) with consumption of ATP , the intermediate product galactose-1-phosphate is formed.

In the further course of the process, a galactose-1-phosphate uridyl transferase (GALT) catalyzes an exchange of UDP- bound glucose with galactose. This creates glucose-1-phosphate and UDP-galactose . While glucose-1-phosphate is isomerized to glucose-6 -phosphate by a phosphoglucomutase (PGM) , a UDP-glucose-4-epimerase (UGE) epimerizes UDP-galactose to UDP-glucose . Glucose-6-phosphate is then broken down further in glycolysis .

Entry of galactose into glycolysis.
Galactose (1), galactose-1-phosphate (2) , UDP-glucose (3), UDP-galactose (4), Glu-1-P (5), Glu-6-P (6).
Galactokinase (GK), galactose-1-phosphate uridyltransferase (GALT), UDP-glucose-4-epimerase (UGE), phosphoglucomutase (PGM)

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  2. ↑ a b c Jan Koolman , Klaus-Heinrich Röhm: Pocket Atlas of Biochemistry. P. 310, 311 ( limited preview in Google Book search).