Marbofloxacin
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| Non-proprietary name | Marbofloxacin | ||||||||||||||||||
| other names |
9-fluoro-2,3-dihydro-3-methyl-10- (4-methyl-1-piperazynyl) -7-oxo-7 H -pyrido [3,2,1- ij ] [4,2,1] benzoxadiazine-6-carboxylic acid |
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| Molecular formula | C 17 H 19 FN 4 O 4 | ||||||||||||||||||
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| Molar mass | 362.36 g · mol -1 | ||||||||||||||||||
| Physical state |
firmly |
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| solubility |
soluble in water |
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| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | |||||||||||||||||||
Marbofloxacin is an antibiotic from the group of fluoroquinolones . It is mainly used in veterinary medicine .
pharmacology
Marbofloxacin is a gyrase inhibitor , i.e. it inhibits an enzyme that is necessary for DNA metabolism and that is specific for bacteria . The drug accumulates in the white blood cells .
Marbofloxacin kills bacteria (bactericidal) against gram-negative and gram-positive pathogens. It shows a good effect against enterobacteria , Pasteurella , pseudomonads and staphylococci .
Marbofloxacin is broken down in the liver into the inactive metabolites N -desmethylmarbofloxacin and N -oxide marbofloxacinin and excreted via the kidneys .
application
Marbofloxacin can be used both orally and parenterally .
It is mainly used for infections of the skin ( pyoderma ), the respiratory tract and the mammary gland ( MMA complex ). In dogs , it is also used for urinary tract infections . The combination preparations with clotrimazole and dexamethasone are used in dogs for ear infections .
The duration of treatment is at least five days.
Contraindications and side effects
Marbofloxacin should not be used in large breeds of dogs younger than 12 or very large breeds of dogs younger than 18 months, as it can damage the cartilage . The product should also not be used during pregnancy , central nervous seizure disorders or existing renal insufficiency .
Quinolones cross the blood-brain barrier and, depending on the dose, inhibit the receptor binding of the neurotransmitter gamma-aminobutyric acid (GABA). This can lead to cramps, but Valium can be used to treat them.
The more harmless side effects are vomiting , diarrhea and anorexia .
Trade names
Monopreparations : Boflox, Efex, Forcyl, Kelacyl, Marbiflox, Marbocyl, Marbokem, Marbonor, Marbox, Marbosol, Marbosyva, Marbotab, Marbox, Marboxidin, Marfloquin, Masterflox, Odimar, Quiflor, Softiflox, Ubiflox
Combination preparations with clotrimazole and dexamethasone : Aurizon, Marbodex, NorOtic, Otoxolan
See also
Web links
- Entry on marbofloxacin at Vetpharm, accessed August 4, 2012.
Individual evidence
- ↑ a b c d data sheet marbofloxacin from Sigma-Aldrich , accessed on May 14, 2017 ( PDF ).
