Serotonin–norepinephrine–dopamine reuptake inhibitor: Difference between revisions

Notice the presence of a γ-amino-alcohol. Although, not immediately obvious to the novice, these are actually PEA derivatives.
Conditions required for PhCHO → Cyclohexanal: Hydrogen bomb.

File:Carlier.GIF

Antidepressant-like effects of novel triple reuptake inhibitors, PRC025 and PRC050 Paul R. Carlier and Elliott Richelson; Yiqun Zhang (2007)

Interactions of antidepressants with neurotransmitter transporters and receptors and their clinical relevance. Elliott Richelson (2003)

The clinical relevance of antidepressant interaction with neurotransmitter transporters and receptors. Richelson E. (2002)

PRC50 is species selective, it behaves differently in rats to humans, wrt DAT.

Eur.J.Pharmacology 555 (007) 30-36.
Compound	hNAT Kd (nM)	hNAT Ki (nM)	hSERT Kd (nM)	hSERT Ki (nM)	hDAT Kd (nM)	hDAT Ki (nM)
PRC050	0.40	1.2	6.0	12	120	43
PRC025	19	10	6.0	6.0	100	53
Venlafaxine	1060	210	9.0	39	9300	5300
Paroxetine	40	33	0.13	0.73	490	1700
Imipramine	37	14	1.4	41	8500	11000
Nomifensine	16.0	5.0	1010	1280	56.3	51
Sertraline	420	220	0.29	3.4	25	260

Im sure you'll enjoy the PRC compounds alot more than Venlafaxine! =D

(gamma) γ-amino alcohol compounds such as those currently being persued by Paul R. Carlier and Elliott Richelson.^[1]^[2]^[3]^[4].
These are antidepressants that are stronger than Venlafaxine[1990].^[5]

Indatraline

Triple Mode Pat Retrieval

Miscellaneous

References

^ [1]European Journal of Pharmacology Volume 555, Issue 1 , 19 January 2007, Pages 30-36
^ United States Patent 6,700,018 Richelson, et al. March 2, 2004
^ United States Patent 6,069,177 Carlier, et al. May 30, 2000
^ [2] Bioorganic & Medicinal Chemistry Letters, V8, Issue 5 , 1998, pp 487-492
^ [3]J. Med. Chem.; 1990; 33(10); 2899-2905.

External links

Template:ChemicalSources Behavioural despair test

[1] [1]European Journal of Pharmacology Volume 555, Issue 1 , 19 January 2007, Pages 30-36

[2] United States Patent 6,700,018 Richelson, et al. March 2, 2004

[3] United States Patent 6,069,177 Carlier, et al. May 30, 2000

[4] [2] Bioorganic & Medicinal Chemistry Letters, V8, Issue 5 , 1998, pp 487-492

[5] [3]J. Med. Chem.; 1990; 33(10); 2899-2905.

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+SNDRI compounds elevate extracellular concentrations of serotonin, norepinephrine and dopamine in the CNS.
-These antidepressant compounds have Pharmacokinetics and Pharmacodynamics completely distinguishable from cocaine/amphetamine etc. Mostly, they dont function as psychostimulants. This is in strong agreement with some of the claims in the [[phenyltropane]] (RTI-112 etc).<br />
-Technically speaking, [[Indatraline]] is a SNDRI, although it is not being actively persued in the context of a clinically useful antidepressant.<br />
-psy·cho·stim·u·lant (sk-stmy-lnt)
-n. A drug having antidepressant or mood-elevating properties. Well obviously I mean, er, LMA stimulant.
 ==Background==
 [http://www.ingentaconnect.com/content/ben/cnsnddt/2007/00000006/00000002 Depression (Part 1) Guest Editors: John H. Kehne and Ronald S. Duman (April 07)]