1,3-propanediol dehydrogenase

In enzymology, a 1,3-propanediol dehydrogenase (EC 1.1.1.202) is an enzyme that catalyzes the chemical reaction

propane-1,3-diol + NAD⁺ $\rightleftharpoons$ 3-hydroxypropanal + NADH + H⁺

Thus, the two substrates of this enzyme are propane-1,3-diol and NAD⁺, whereas its 3 products are 3-hydroxypropanal, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is propane-1,3-diol:NAD+ 1-oxidoreductase. Other names in common use include 3-hydroxypropionaldehyde reductase, 1,3-PD:NAD+ oxidoreductase, 1,3-propanediol:NAD+ oxidoreductase, and 1,3-propanediol dehydrogenase. This enzyme participates in ether lipid metabolism as a step in glycerolipid biosynthesis.

References

• ABELES RH, BROWNSTEIN AM, RANDLES CH (1960). "beta-Hydroxypropionaldehyde, an intermediate in the formation of 1,3-propanediol by Aerobacter aerogenes". Biochim. Biophys. Acta. 41: 530–1. PMID 13791444.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Forage RG, Foster MA (1982). "Glycerol fermentation in Klebsiella pneumoniae: functions of the coenzyme B12-dependent glycerol and diol dehydratases". J. Bacteriol. 149: 413–9. PMID 7035429.

External links

The CAS registry number for this enzyme class is Template:CAS registry.