James McGuire
James McGuire may refer to:
- James McGuire (VC) (1827–1857), Irish recipient of the Victoria Cross
- Deacon McGuire (1863–1936), American baseball player
- James G. Maguire (1853-1920), United States Representative from California
- James Kennedy McGuire, American politician, mayor of Syracuse, New York
- James McGuire (Texas politician), active 19th century
- James McGuire (Irish politician) (1903-1989), Irish Cumann na nGaedhael politician
- Jimmy McGuire, member of the Jeopardy! Clue Crew