Reid Hunt
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Reid Hunt (1870 - 1948)[1], who is known for his work on adrenal glands, extracts from which cause rise in blood pressure due to its content of adrenaline. When he removed the adrenaline from the extract and he found that it causes fall in blood pressure, which he concluded was due to a derivative of choline, later on called as acetylcholine.
"I frequently obtained extracts of the suprarenal (and also of the brain) which caused a fall of blood pressure... and which were also more powerful than choline... I also got results...which led me to think that at least some of these results were to be attributed to a precursor of choline or to some compound of choline...From these observations it seemed not impossible that...cholin or to some compounds may have some importance in certain pathological conditions...acetylcholine the first of this series, is a substance of extraordinary physiological activity. In fact, i think it safe to state that as regards its effect upon the circulation, it is the most powerful substance known...we have not determined the cause of the fall of blood pressure from acetylcholine, but from the fact that it can be prevented entirely by atropine, I am inclined to think that it is due to an effect upon the terminations of the vagus in the heart."
Commentry made by Reid Hunt in a paper published along with Taveau in the year 1906 [2]
| Born | April 20, 1870 Martinsville, Ohio |
|---|---|
| Died | March 7, 1948 Belmont, Massachusetts |
| Known for | Acetylcholine |
| Notable work | Pharmacological action of acetylcholine |
Research
- Embryology of polipterus, he carried out the studies in egypt.
- Methyl alcohol toxicity.
- Activity of acetylcholine.
- Thyroid gland iodine content and its physiological activity, during this study he demonstrated the presence of thyroid hormone in the human blood.
Positions held
- Tutor in physiology (1896-1898), Columbia university medical school.
- Chief of pharmacological division (1904-1913), Hygienic laboratory,U.S. public health service.
- Chair of pharmacology, Harvard medical school.
- Chairman of council on pharmacy and chemistry of the american medical association.
- President of pharmacopeial convention.
- Chairman of northeastern section of american chemical society.
- Secretory and president of american society for pharmacology and experimental therapeutics.
- Chairman of the section of on pharmacology and therapeutics of american medical association.
- Consultant for chemical warfare service, U.S. army
- Consultant, Massachusetts state board of health
- Consultant, Hygienic laboratory.
- Member, Drug standardisation committee of league of nations.
References
- ^ Grabfield, G. Philip (August 1948). "Reid Hunt, 1870-1948". Science. 108 (2797): 127. doi:10.1126/science.108.2797.127. PMID 17806855. Retrieved 10 January 2018.
- ^ Israel., Hanin, (1986). Dynamics of Cholinergic Function. Boston, MA: Springer US. ISBN 9781468451948. OCLC 851818367.
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