Allotopic expression
Expression from the nuclear genome of genes that normally are expressed only from the mitochondrial genome is referred to as allotopic expression (AE). Biomedically engineered AE has been suggested as a possible future tool in gene therapy of certain mitochondria-related diseases (de Grey 2000).
References
- de Grey, Aubrey D. N. J. (2000): Mitochondrial gene therapy: an arena for the biomedical use of inteins. Trends in Biotechnology 18(9): 394-399 doi:10.1016/S0167-7799(00)01476-1 (HTML abstract)
- Oca-Cossio et al, Limitations of allotopic expression of mitochondrial genes in mammalian cells. Genetics. 2003 Oct;165(2):707-20 18(9): 394-399 Template:Http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=14573482 (abstract & full article)