Metabolomics

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This is an old revision of this page, as edited by Jgbundy (talk | contribs) at 17:29, 15 October 2004 (Added comment about FT-ICR-MS under MS sub-head, and deleted listing of FTIR as a 'key technique'. FTIR allows 'metabolic fingerprinting' but does not ID individual metabolites.). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Metabolomics is the study of the metabolic profile of a given cell, tissue, fluid, organ or organism at a given point in time. The metabolome represents the end products of gene expression. While mRNA gene expression data and proteomic analyses hint at what might be happening in a cell, metabolites and their relative accumulation can indicate what is happening that cell.

Key technologies

  • Mass spectrometry particularly gas chromatography mass spectrometry (GC MS), and liquid chromatography mass spectrometry (LC MS). In addition, direct-infusion mass spectrometry is becoming increasingly popular, especially for high-resolution techniques such as Fourier-transform ion-cyclotron-resonance mass spectrometry (FT-ICR-MS).
  • High pressure liquid chromatography (HPLC).
  • Nuclear magnetic resonance (NMR) spectrometry


See also: proteomics, glycomics

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