Radicicol
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| Names | |
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| IUPAC name
(1aR,2E,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione
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| Identifiers | |
| ECHA InfoCard | 100.170.695 |
PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |
| C18H17ClO6 | |
| Molar mass | 364.78 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Radicicol, also known as monorden, is a natural product that binds to Hsp90 (Heat Shock Protein 90) and alters its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.
Further reading
- Wimssinger N, Barluanga S (2005). "Chemistry and biology of resorcylic acid lactones". Chem Commun (1): 22–36. doi:10.1049/b610344h. PMID 17277252.
{{cite journal}}: Unknown parameter|month=ignored (help) Review of the chemistry and biology of resorcylic acid lactones, including radicicol.
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