William Mathews
William Mathews may refer to:
- Bill Mathews (William Henry Mathews, 1919–2003), Canadian geologist
- William Matthews (baseball) (1878–1946), American baseball player
- William Mathews (cricketer) (1793–1858), English cricketer
- William Mathews (mountaineer) (1828–1901), English mountaineer and botanist
- William A. Mathews, 19th-century Texas colonist, soldier, courier and quartermaster in the Texas Revolution