Adaptive deactivation

The Adaptive deactivation attempts to induce tolerance against it at a low dose of an active ingredient. It is mainly used in the case of intolerance to acetylsalicylic acid (ASA, aspirin), which among other things leads to asthma attacks, and in the presence of a Samter triad . The concept of adaptive deactivation is based on the fact that one to three days after the occurrence of an intolerance reaction to ASA, no further reaction can be triggered by the active substance; one speaks of a refractory phase. Adaptive deactivation uses the refractory phase to build up a tolerance to the active ingredient with regular doses of ASA. Since this is not a matter of desensitization , as the ASA intolerance is not based on an allergy.

supporting documents

• Thomas Herdegen: Short textbook pharmacology and toxicology . 3. Edition. Georg Thieme, Stuttgart / New York 2014, ISBN 978-3-13-142293-4 , pp. 347 .
• Nicole Schuster: Intolerance: Deactivate or avoid ASD. Pharmaceutical newspaper, November 30, 2018. Last accessed on March 29, 2020.

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