Bezold-Jarisch reflex

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The Bezold-Jarisch reflex is a reflex emanating from the heart muscle . The reflex was named after the German physiologist Albert von Bezold (1836–1868) and the Austrian pharmacologist Adolf Jarisch junior (1891–1965).

The Bezold-Jarisch reflex is regarded as a combination of a cardiocardial self-reflex ( bradycardia ) and a cardiovascular external reflex ( hypotension ). In addition to the irritation of stretch receptors, chemical irritation (e.g. in hypoxic conditions) in the left ventricle is suspected to be the cause.

Jarisch came across Albert von Bezold's investigations by chance because one of his employees regularly had sneezing attacks while pulverizing mistletoe leaves. This prompted Jarisch to read about the hellebore, where he found von Bezold's work on the effects of veratrin . Jarisch dealt intensively with this "Bezold effect", which he described, and published twelve further papers between 1939 and 1949 to elucidate the physiological and pharmacological mechanisms.

The term "Bezold-Jarisch-Reflex" is used for the first time in Schäfer. The exact reflex events have not yet been finally clarified.

literature

  • Ernst F. Gersmeyer: The circulatory collapse. Springer, 1961. (Edition 2013 ISBN 978-3-642-86146-8 .)
  • Sebastian Schulz-Stübner: Regional anesthesia and analgesia: techniques and therapy schemes for practice. Schattauer Verlag, Stuttgart 2003, ISBN 3-7945-2192-7 .

Individual evidence

  1. ↑ Christoff Zalpour (Ed.): Springer Lexikon Physiotherapie. Springer, 2014, ISBN 978-3-642-34730-6 , p. 163.
  2. ↑ Ernst F. Gersmeyer: The circulatory collapse. Springer, 1961, OCLC 488431839 , p. 152 ff.
  3. ↑ Alexander Zuber: Veratrin. On the origin and impact of the Bezold-Jarisch reflex, with a facsimile of Ludwig Hirt's dissertation in Breslau. (Medical dissertation, Würzburg 1989) Königshausern & Neumann, Würzburg 1990 (= Würzburg medical-historical research , 48).
  4. ↑ Adolf Jarisch and Hans Richter, The Bezold Effect - a forgotten circulatory reaction, Klin.Wschr.18 (1937), pp. 185–187.
  5. ↑ Hans Schäfer, On the sensitivity of heart and skeletal muscles and their clinical significance, Klin.Wschr.22 (1943), pp. 553-560.
  6. ↑ Alexander Zuber: Veratrin - On the history of the origins and effects of the Bezold-Jarisch reflex; Diss. Würzburg 1989, pp. 57-59.