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Bretholz is the family name of the following people:

Alexandre Bretholz (* 1944), Swiss fencer
Berthold Bretholz (also: Bertold Bretholz; 1862–1936), Bohemian historian and archivist
Leo Bretholz († 2014), Austrian-American Holocaust survivor
Wolfgang Bretholz (pseudonyms: Walther Bartz and Otto Olm; 1904–1969), German-Swiss journalist