CD31

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Platelet-Endothelial Cell Adhesion Molecule (PECAM-1) also known as Cluster of Differentiation 31 (CD31) is a protein that is encoded on chromosome 17 in the human genome. PECAM-1 plays a key role in clearing aged neutrophils from the body.

function

PECAM-1 is expressed in high levels on the surface of early and mature endothelial cells , platelets , monocytes , neutrophils , and some types of T cells . Expression on endothelial cells is concentrated in connections between neighboring cells. The encoded protein is a member of the immunoglobulin superfamily . PECAM-1 is involved in angiogenesis, platelet function and thrombosis. Its primary function on endothelial cells is to control leukocyte transmigration and it also serves as a mechanosensor for shear stress.

Individual evidence

  1. ↑ a b Entrez Gene: platelet / endothelial cell adhesion molecule . Retrieved June 25, 2014.
  2. ↑ Newman PJ, Berndt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA: PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily . In: Science . 247, No. 4947, March 1990, pp. 1219-22. doi : 10.1126 / science.1690453 . PMID 1690453 .
  3. ↑ Gumina RJ, Kirschbaum NE, Rao PN, vanTuinen P, Newman PJ: The human PECAM1 gene maps to 17q23 . In: Genomics . 34, No. 2, June 1996, pp. 229-32. doi : 10.1006 / geno.1996.0272 . PMID 8661055 .
  4. ↑ Xie Y, Muller WA: Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1 . In: Genomics . 37, No. 2, October 1996, pp. 226-8. doi : 10.1006 / geno.1996.0546 . PMID 8921400 .