Castillo y Guzmán
Castillo y Guzmán is a family name that may refer to:
- Juan Argüello del Castillo y Guzmán (1778–1830), Nicaraguan politician, head of state 1826/1827 and 1828/1829
- Nicasio del Castillo y Guzmán (1830– ??), Nicaraguan politician, president 1856