Chromatolysis
As chromatolysis or tigrolysis is mainly in the neuropathology the disappearance of Nissl bodies in nerve cells , respectively. However, Nissl clods can also be stained in other cell types and react in a similar way there. These changes are very reactive cellular processes that can be traced back to very different initial situations and, in particular, to damage to the cell. These include hunger , overload, hypoxia (lack of oxygen), infectious and toxic damage to the nerve cell and, in particular, reactions after severing the neurite.
Pathological anatomy
The regression of the tigroid clods is accompanied by characteristic cell changes. The Nissl substance is only retained in nerve cells in the vicinity of the cell membrane; it can no longer be detected inside the cell. The cell nuclei are also shifted to the periphery of the cell. A cap of chromaffin substances sits on them. The result is the image of the so-called fish-eye cells. In this context, Waller's degeneration often occurs . In neuropathology, some benign tumors such as the ganglioneuroma can be diagnosed by the fact that the tigroid clods are still visible.
Individual evidence
- ^ Chromatolysis. In: Norbert Boss (Ed.): Roche Lexicon Medicine. 2nd Edition. Hoffmann-La Roche AG and Urban & Schwarzenberg, Munich 1987, ISBN 3-541-13191-8 , p. 303, Gesundheit.de/roche
- ↑ Ergastoplasm. In: Norbert Boss (Ed.): Roche Lexicon Medicine. 2nd Edition. Hoffmann-La Roche AG and Urban & Schwarzenberg, Munich 1987, ISBN 3-541-13191-8 , p. 519, Gesundheit.de/roche
- ↑ Nissl substance. In: Helmut Ferner : Anatomy of the nervous system and the human sensory organs. 2nd Edition. Reinhardt, Munich 1964, p. 22 ff.
- ↑ Tigroid clods. In: Hans Ulrich Zollinger : Pathological Anatomy . Volume 1: General Pathology. Georg Thieme, Stuttgart 1968, p. 276.