Diamidophosphates

Diamidophosphoric acid and its derivatives
Diamidophosphoric acid
Diamidophosphoric acid anion
Diamidophosphoric acid sodium salt CAS no. 17097-14-2
Diamidophosphoric acid ammonium salt CAS no. 13597-81-4

Diamidophosphates are a group of chemical compounds. These are the salts and esters of diamidophosphoric acid (CAS No. 10043-91-1). The anion is called diamidophosphate , or DAP for short , is an organic phosphate-amino compound and is one of the phosphoramidates .

Effect and meaning

Because of its similarity to diamido hydrogen orthocarbonate, DAP is an effective inhibitor of urease (transition state analog ).

DAP has been linked as a possible phosphorylating agent in the prebiotic evolution of the first organic compounds and precursor molecules of earthly life such as peptides, lipids or nucleotides.

Web links

Jan Osterkamp: Prebiotic Evolution: Kickstarter of Life in the Primordial Soup. In: Spektrum.de. November 6, 2017. Retrieved November 7, 2017 .

Individual evidence

↑ Sonja Herres-Pawlis, Peter Klüfers: Bioinorganic Chemistry: Metalloproteins, Methods and Models . John Wiley & Sons, 2017, ISBN 978-3-527-67549-4 , pp. 18 ( limited preview in Google Book search).
↑ Clémentine Gibard et al .: Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions . In: Nature Chemistry . 2017, doi : 10.1038 / nchem.2878 .

[1] Sonja Herres-Pawlis, Peter Klüfers: Bioinorganic Chemistry: Metalloproteins, Methods and Models . John Wiley & Sons, 2017, ISBN 978-3-527-67549-4 , pp. 18 ( limited preview in Google Book search).

[2] Clémentine Gibard et al .: Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions . In: Nature Chemistry . 2017, doi : 10.1038 / nchem.2878 .