One-pot reaction
In preparative chemistry and chemical engineering, a one- pot reaction is understood to be a chemical synthesis , which is characterized by the fact that as many reagents and solvents as possible are initially stored in one vessel (laboratory: round-bottom flasks , three-necked flasks , Erlenmeyer flasks , etc .; technology: reaction vessel , Kettle cascade, flow tube) and then allowed to react (mostly with stirring / mixing and heating or cooling). Sometimes individual components are added in the course of the operation (preferably via a dropping funnel or other metering device). As soon as the reaction is over, the reaction mixture is worked up and the product is obtained, for example by precipitation , crystallization or distillation .
One-pot reactions do not require the isolation of intermediate products and usually only little expenditure on equipment. This saves material, time and energy , which is why synthetic chemists and technicians choose the reaction conditions for many important intermediate and end products so that the synthesis can be carried out as a one-pot reaction.
The term was translated literally into English as one-pot reaction or one-pot synthesis and is used in the same sense in Anglophone literature.
Well-known examples of one-pot reactions are the Asinger reaction and the Ugi reaction .
Individual evidence
- ^ Carine Vaxelaire, Philipp Winter, Mathias Christmann: One-pot reactions accelerate the synthesis of active pharmaceutical ingredients. In: Angewandte Chemie. 123, 2011, p. 3685, doi : 10.1002 / ange.201100059 .
- ↑ Friedrich Asinger , Manfred Thiel: Simple syntheses and chemical behavior of new heterocyclic ring systems. In: Angewandte Chemie. 70, No. 22-23, 1958, pp. 667-683, doi : 10.1002 / anie.19580702202 .