Flying syringe

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“Flying syringes” is a term used for transgenic mosquitoes that inject a vaccine with their secretion when an insect bites . The term is also used obsolete for blood-sucking insects that transmit infectious diseases.

properties

In 2008, the Gates Foundation awarded US $ 100,000 in research grants to Hiroyuki Matsuoka of Jichi Medical University in Japan for research into the flying syringe for use in a malaria vaccine , on condition that the research results be released for commercial use in developing countries. If successful, there is the option of a subsequent grant of $ 1,000,000. The newspaper The Washington Post called flying syringes as "foolhardy idea" ( English bold idea ). Initial vaccination attempts with transgenic malaria mosquitoes ( Anopheles stephensi ), which produced the circumsporozoite protein (CSP) from plasmodia in their salivary glands, failed because the CSP was not secreted from the salivary glands . In 2012, the first successful immunization tests were carried out with mosquitoes that use the red fluorescent protein DsRed. secrete into the host when bitten.

Individual evidence

  1. ^ Robert A. Guth: Rocket Scientists Shoot Down Mosquitoes With Lasers. In: Wall Street Journal. March 14, 2009. Retrieved November 27, 2017 .
  2. ↑ JL Kenney, AC Brault: The role of environmental, virological and vector interactions in dictating biological transmission of arthropod-borne viruses by mosquitoes. In: Adv Virus Res. (2014). Volume 89, pp. 39-83. doi: 10.1016 / B978-0-12-800172-1.00002-1 . PMID 24751194 .
  3. ↑ Tim Johnston: Flying Syringes and Other Bold Ideas. In: The Washington Post. October 23, 2008, accessed November 27, 2017 .
  4. ↑ H. Matsuoka, T. Ikezawa, M. Hirai: Production of a transgenic mosquito expressing circumsporozoite protein, a malarial protein, in the salivary gland of Anopheles stephensi (Diptera: Culicidae). In: Acta Med Okayama. Volume 64, Issue 4, 2010, pp. 233-241. PMID 20802540 .
  5. ↑ H. Matsuoka, G. Sano, R. Hattori, H. Tomita, DS Yamamoto, M. Hirai: One Injection of DsRed Followed by Bites from Transgenic Mosquitoes Producing DsRed in the Saliva Elicits a High Titer of Antibody in Mice. In: Trop Med Health. Volume 40, Issue 2, 2012, pp. 47-52. doi: 10.2149 / tmh.2011-10 . PMID 23097619 ; PMC 3473083 (free full text).