Flood reaction
The Flood reaction , named after the chemist EA Flood, is a name reaction from organic chemistry and was first published in 1933. The reaction describes the synthesis of halotrialkylsilanes from a hexaalkyldisiloxane.
Overview reaction
A hexaalkyldisiloxane reacts with an ammonium halide and sulfuric acid to form a halotrialkylsilane.
Reaction mechanism
The mechanism is described in the literature and is illustrated with ammonium chloride :
A hexaalkyldisiloxane 1 initially reacts with the addition of sulfuric acid to form an unstable intermediate 2 . Subsequent dehydration gives a bis (trialkylsilyl) sulfate 3 .
3 reacts with the addition of ammonium chloride and elimination of chlorotrialkylsilane to form an ionic intermediate 4 . The reaction of 4 with ammonium chloride gives the halotrialkylsilane 5 after liberation of ammonium sulfate .
Individual evidence
- ^ EA Flood (1933), Preparation of Triethylsilicon Halides Journal of the American Chemical Society 55 (4), 1735-1736 doi: 10.1021 / ja01331a504 .
- ↑ LH summer, EW Pietrusza, GT Kerr and FC Whitmore (1946), trialkylsilyl sulfate , Journal of the American Chemical Society 68 (1), p 156, doi: 10.1021 / ja01205a523 .
- ^ Z. Wang: Comprehensive organic name reactions and reagents Volume 1 . John Wiley, Hoboken (NJ) 2009, ISBN 978-0-470-28662-3 , pp. 1107-1109 .