Frankland Duppa Reaction

The Frankland-Duppa reaction is a name reaction in organic chemistry . The reaction was named after the English chemist Edward Frankland (1825–1899) and is used to produce 2-hydroxycarboxylic acid alkyl esters. The Frankland Duppa reaction is not to be confused with the Frankland reaction. These are two different reactions.

Overview reaction

In the Frankland-Duppa reaction of a dialkyl oxalate 1 with haloalkanes (e.g. iodoalkanes) in the presence of zinc (or zinc amalgam ) and hydrochloric acid, a 2-hydroxycarboxylic acid alkyl ester 2 is formed .

Individual evidence

^ The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals, 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006; P. 34, ISBN 978-0-911910-00-1 .

[MERCK_Index-1] The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals, 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006; P. 34, ISBN 978-0-911910-00-1 .