Ganglion blockers

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Ganglion blockers are also called ganglioplegics and inhibit the transmission of excitation to sympathetic and parasympathetic ganglia . The blockage occurs through:

Ganglion blockers are no longer used frequently because both legs of the vegetative part are blocked in an undifferentiated manner. This leads to numerous side effects.

A ganglion blockade is the interruption in the transmission of nerve impulses from the vegetative nervous system by means of chemical substances.

Active ingredients

In a study, various active ingredients were examined for their blocking effect on the nerve activity of the ganglia. The following table lists the most important ones; the active ingredients are compared with tetraethylammonium ion, which reduces nerve activity by 40% at the same dose.

Active ingredient Activity in%
Tetraethylammonium ion 100
Amobarbital 74
Pentobarbital 33
Benactyzin 17th
Hydroxyzine 10
Mephobarbital 9
phenobarbital 6th
Carbromal 6th

Individual evidence

  1. ^ DA Brown, JP Quilliam: The effects of some centrally acting drugs on ganglionic transmission in the cat. PMC 1704089 (free full text, PDF)