Ganglion blockers
Ganglion blockers are also called ganglioplegics and inhibit the transmission of excitation to sympathetic and parasympathetic ganglia . The blockage occurs through:
- Stabilization of the postsynaptic membrane (tetraethylammonium)
- due to long-term depolarization after prior strong arousal (nicotine)
Ganglion blockers are no longer used frequently because both legs of the vegetative part are blocked in an undifferentiated manner. This leads to numerous side effects.
A ganglion blockade is the interruption in the transmission of nerve impulses from the vegetative nervous system by means of chemical substances.
Active ingredients
In a study, various active ingredients were examined for their blocking effect on the nerve activity of the ganglia. The following table lists the most important ones; the active ingredients are compared with tetraethylammonium ion, which reduces nerve activity by 40% at the same dose.
| Active ingredient | Activity in% |
|---|---|
| Tetraethylammonium ion | 100 |
| Amobarbital | 74 |
| Pentobarbital | 33 |
| Benactyzin | 17th |
| Hydroxyzine | 10 |
| Mephobarbital | 9 |
| phenobarbital | 6th |
| Carbromal | 6th |
Individual evidence
- ^ DA Brown, JP Quilliam: The effects of some centrally acting drugs on ganglionic transmission in the cat. PMC 1704089 (free full text, PDF)
