George O'Brien (disambiguation)
George O'Brien is the name of the following people:
- George O'Brien (soccer player, 1880) (1880– ??), English soccer player
- George O'Brien (1899–1985), American actor
- George O'Brien (soccer player, 1935) (born 1935), Scottish soccer player
- George O'Brien (soccer player, 1939) (1939-1995), English soccer player
- George D. O'Brien (1900–1957), American politician
- George M. O'Brien (1917–1986), American politician
