George Spencer
George Spencer is the name of the following people:
- George Spencer, 2nd Earl Spencer (1758–1834), British nobleman and politician (Whig)
- George Spencer, 4th Duke of Marlborough (1739-1817), British nobleman and politician
- George Spencer-Brown (1923–2016), British mathematician, psychologist, poet and chess player
- George Spencer-Churchill, 5th Duke of Marlborough (1766–1840), British nobleman and politician
- George Spencer-Churchill, 6th Duke of Marlborough (1793–1857), British nobleman and politician
- George Spencer-Churchill, 8th Duke of Marlborough (1844-1892), British nobleman
- George E. Spencer (1836-1893), American politician