HAMA answer
The term HAMA response is short for Human Anti-Mouse Antibody Response . It is the response the human immune system builds to mouse antibodies . There is cross-reactivity with antibodies from other mammals. The HAMA response increases with increasing therapy length, so that the mouse antibodies are neutralized and the therapy becomes ineffective. Through the development of chimeric antibodies or humanized antibody or the production of recombinant antibodies using phage display libraries (see also phage display ), the human immunoglobulin - genes contain this problem is to be avoided in the future.
literature
- Keyword “HAMA answer.” In: Herder-Lexikon der Biologie. Spectrum Akademischer Verlag GmbH, Heidelberg 2003. ISBN 3-8274-0354-5 .
Individual evidence
- ↑ Stefan Dübel, Frank Breitling, André Frenzel: Recombinant Antibodies. Springer-Verlag, 2019, ISBN 3662502763 p. 89.
- ^ Poultry Science. Poultry Science Association, 1993, vol. 72, p. 1809.