HBG2

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HBG2
HBG2
Structure of the HBG2 protein
Identifier
Gene name (s) HBG2
External IDs

The subunit hemoglobin gamma-2 is a protein encoded by the HBG2 gene present in humans.

function

The gammaglobin genes (HBG1 and HBG2) are usually expressed in the fetal liver , spleen, and bone marrow . Two gamma chains together with two alpha chains form fetal hemoglobin ( HbF ), which is normally replaced by adult hemoglobin ( HbA ) at birth . With some beta thalassemia and the associated conditions, the production of gamma chains continues into adulthood. The two types of gamma chains differ at amino acid 136, where glycine is found in G-gamma production (HBG2) and alanine in A-gamma production (HBG1) . The former is predominant at birth . The order of the genes in the beta-globin cluster is: 5 '- ε - γ-G - γ-A - δ - β - 3'.

Individual evidence

  1. Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ: A review of the molecular genetics of the human alpha-globin gene cluster . In: Blood . 73, No. 5, May 1989, pp. 1081-104. PMID 2649166 .
  2. Entrez: hbg2 hemoglobin, gamma G . Retrieved May 19, 2012.

literature

  • Gelinas R, Yagi M, Finally B, et al. : Sequences of G gamma, A gamma, and beta genes of the Greek (A gamma) HPFH mutant: evidence for a distal CCAAT box mutation in the A gamma gene. . In: Prog. Clin. Biol. Res . 191, 1985, pp. 125-39. PMID 2413469 .
  • Anderson NL, Anderson NG: The human plasma proteome: history, character, and diagnostic prospects. . In: Mol. Cell Proteomics . 1, No. 11, 2003, pp. 845-67. doi : 10.1074 / mcp.R200007-MCP200 . PMID 12488461 .