Hookworm vaccine

Hookworms of the species Ancylostoma caninum

A hookworm vaccine is a vaccine against hookworms .

properties

The human pathogens from the genus Ancylostomatidae are Necator americanus and Ancylostoma duodenale . Both can be treated safely and effectively with mebendazole or albendazole , but effectiveness ends with treatment and does not protect against re-infestation. In the course of development of vaccines are used as antigens , the proteins Na-ASP-2 ( Ancylostoma Secreted Protein-2 ), and Na-GST-1 of N. americanus , and Ac-APR 1 (a hemoglobinase from the group of aspartic proteases ) from Ancylostoma caninum examined . A hookworm vaccine for dogs was developed in the 1970s.

literature

• PJ Hotez, J. Bethony, ME Bottazzi, S. Brooker, P. Buss: Hookworm: "the great infection of mankind". In: PLOS Medicine. Volume 2, number 3, March 2005, p. E67, doi : 10.1371 / journal.pmed.0020067 , PMID 15783256 , PMC 1069663 (free full text).

Individual evidence

1. ↑ B. Schneider, AR Jariwala, MV Periago, MF Gazzinelli, SN Bose, PJ Hotez, DJ Diemert, JM Bethony: A history of hookworm vaccine development. In: Human vaccines. Volume 7, number 11, November 2011, pp. 1234-1244, doi : 10.4161 / hv.7.11.18443 , PMID 22064562 , PMC 3323499 (free full text).
2. ↑ DJ Diemert, JM Bethony, PJ Hotez: Hookworm vaccines. In: Clinical Infectious Diseases . Volume 46, Number 2, January 2008, pp. 282-288, doi : 10.1086 / 524070 , PMID 18171264 .
3. ↑ ^{a b} A. Loukas, JM Bethony, S. Mendez, RT Fujiwara, GN Goud, N. Ranjit, B. Zhan, K. Jones, ME Bottazzi, PJ Hotez: Vaccination with recombinant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogs. In: PLOS Medicine . Volume 2, number 10, October 2005, p. E295, doi : 10.1371 / journal.pmed.0020295 , PMID 16231975 , PMC 1240050 (free full text).
4. ↑ JM Bethony, G. Simon, DJ Diemert, D. Parenti, A. Desrosiers, S. Schuck, R. Fujiwara, H. Santiago, PJ Hotez: Randomized, placebo-controlled, double-blind trial of the Na-ASP- 2 hookworm vaccine in unexposed adults. In: Vaccine. Volume 26, Number 19, May 2008, pp. 2408-2417, doi : 10.1016 / j.vaccine.2008.02.049 , PMID 18396361 .
5. ↑ AR Jariwala, LM Oliveira, DJ Diemert, B. Keegan, JL Plieskatt, MV Periago, ME Bottazzi, PJ Hotez, JM Bethony: Potency testing for the experimental Na-GST-1 hookworm vaccine. In: Expert review of vaccines. Volume 9, number 10, October 2010, pp. 1219-1230, doi : 10.1586 / erv.10.107 , PMID 20923271 .
6. ↑ PJ Hotez, D. Diemert, KM Bacon, C. Beaumier, JM Bethony, ME Bottazzi, S. Brooker, AR Couto, M. d. Freire, A. Homma, BY Lee, A. Loukas, M. Loblack, CM Morel, RC Oliveira, PK Russell: The Human Hookworm Vaccine. In: Vaccine. Volume 31 Suppl 2, April 2013, pp. B227 – B232, doi : 10.1016 / j.vaccine.2012.11.034 , PMID 23598487 , PMC 3988917 (free full text).
7. ^ TA Miller: Vaccination against the canine hookworm diseases. In: Advances in parasitology. Volume 9, 1971, pp. 153-183, PMID 4932829 .

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !